Abstract
An accumulating body of evidence point to the significance of neuroinflammation and immunogenetics also in schizophrenia. Recent genome-wide studies in schizophrenia suggest immune involvement in schizophrenia. Microglia are the resident macrophage of the brain and major players in innate immunity in the CNS. They respond rapidly to even minor pathological changes in the brain and may contribute directly to the neuronal degeneration by producing various pro-inflammatory cytokines and free radicals. In many aspects, the neuropathology of schizophrenia is closely associated with microglial activation. We and other researchers have shown the inhibitory effects of some typical or atypical antipsychotics on the release of inflammatory cytokines and free radicals from activated microglia, both of which are not only directly toxic to neurons but also cause a decrease in neurogenesis as well as white matter abnormalities in the brains of the patients with schizophrenia. The treatment through the inhibition of microglial activation may shed new light on the therapeutic strategy of schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 115-121 |
| Number of pages | 7 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 42 |
| DOIs | |
| Publication status | Published - Apr 5 2013 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Biological Psychiatry
Cite this
Neuroinflammation in schizophrenia especially focused on the role of microglia. / Monji, Akira; Kato, Takahiro; Mizoguchi, Yoshito; Horikawa, Hideki; Seki, Yoshihiro; Kasai, Mina; Yamauchi, Yusuke; Yamada, Shigeto; Kanba, Shigenobu.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 42, 05.04.2013, p. 115-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroinflammation in schizophrenia especially focused on the role of microglia
AU - Monji, Akira
AU - Kato, Takahiro
AU - Mizoguchi, Yoshito
AU - Horikawa, Hideki
AU - Seki, Yoshihiro
AU - Kasai, Mina
AU - Yamauchi, Yusuke
AU - Yamada, Shigeto
AU - Kanba, Shigenobu
PY - 2013/4/5
Y1 - 2013/4/5
N2 - An accumulating body of evidence point to the significance of neuroinflammation and immunogenetics also in schizophrenia. Recent genome-wide studies in schizophrenia suggest immune involvement in schizophrenia. Microglia are the resident macrophage of the brain and major players in innate immunity in the CNS. They respond rapidly to even minor pathological changes in the brain and may contribute directly to the neuronal degeneration by producing various pro-inflammatory cytokines and free radicals. In many aspects, the neuropathology of schizophrenia is closely associated with microglial activation. We and other researchers have shown the inhibitory effects of some typical or atypical antipsychotics on the release of inflammatory cytokines and free radicals from activated microglia, both of which are not only directly toxic to neurons but also cause a decrease in neurogenesis as well as white matter abnormalities in the brains of the patients with schizophrenia. The treatment through the inhibition of microglial activation may shed new light on the therapeutic strategy of schizophrenia.
AB - An accumulating body of evidence point to the significance of neuroinflammation and immunogenetics also in schizophrenia. Recent genome-wide studies in schizophrenia suggest immune involvement in schizophrenia. Microglia are the resident macrophage of the brain and major players in innate immunity in the CNS. They respond rapidly to even minor pathological changes in the brain and may contribute directly to the neuronal degeneration by producing various pro-inflammatory cytokines and free radicals. In many aspects, the neuropathology of schizophrenia is closely associated with microglial activation. We and other researchers have shown the inhibitory effects of some typical or atypical antipsychotics on the release of inflammatory cytokines and free radicals from activated microglia, both of which are not only directly toxic to neurons but also cause a decrease in neurogenesis as well as white matter abnormalities in the brains of the patients with schizophrenia. The treatment through the inhibition of microglial activation may shed new light on the therapeutic strategy of schizophrenia.
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U2 - 10.1016/j.pnpbp.2011.12.002
DO - 10.1016/j.pnpbp.2011.12.002
M3 - Article
C2 - 22192886
AN - SCOPUS:84873524397
VL - 42
SP - 115
EP - 121
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
ER -