Neurokinin A suppresses a voltage-gated K+ current in smooth muscle cells from rat vas deferens

Nakazawa Ken Nakazawa, Kazuhide Inoue, Fujimori Kannosuke Fujimori, Takanaka Akira Takanaka

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The effects of neurokinin A (NKA) on freshly isolated smooth muscle cells from the rat vas deferens were investigated electrophysiologically. NKA (10-7 M) prolonged the duration of action potentials without affecting resting potentials. Under voltage-clamp conditions, NKA (10-7 M) suppressed an outward K+ current activated by depolarizing voltage steps. Substance P (SP, 10-7 M) did not affect the K+ current, suggesting that NKA is more potent in suppressing the K+ current than SP is, as is also true for the contractions of smooth muscles of the rat vas deferens. The suppression of the K+ conductance now reported may contribute to NKA-induced smooth muscle contraction.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalEuropean Journal of Pharmacology
Volume182
Issue number1
DOIs
Publication statusPublished - Jun 21 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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