Neurological signs and symptoms in patients with chronic PCB poisoning (Yusho accident) for more than 36 years

Hirokazu Furuya, Takeshi Yamada, Yasumasa Ohyagi, Koji Ikezoe, Tasuku Miyoshi, Naoki Fujii, Jun-Ichi Kira

Research output: Contribution to journalArticle

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Abstract

Background: The existence of peripheral neuropathy after chronic exposure to polychlorinated biphenyls (PCBs) is still controversial because studies concerning the effects of PCBs on the peripheral nervous system are rare. Objective: The purpose of this study was to determine the correlation between neurological signs and symptoms and the concentration of serum PCBs. Materials and methods: Neurological data collected from the results of a nationwide health examination of 450 male and 557 female Yusho victims (chronic PCB poisoning) exposed more than 36 years ago were compared with recent measurements of the serum PCB concentration and patterns. Results: The frequency of sensory disturbance detected by neurological examination was significantly higher in the group of officially acknowledged victims (male, P = 0.014; female, P = 0.001) than in age-matched controls. Significant differences were not observed between the serum PCB patterns and the neurological findings, but the serum PCB concentration was significantly higher in the group with decreased tendon reflex in officially and non-officially acknowledged female Yusho victims (male, P = 0.994; female, P = 0.014). Conclusion: These results suggest that the long half-life of PCBs and their accumulation in fatty tissue can lead to persistent mild impairment of the peripheral nervous system even long after exposure.

Original languageEnglish
JournalJournal of Dermatological Science, Supplement
Volume1 SUPPL.
Issue number1
DOIs
Publication statusPublished - Apr 1 2005
Externally publishedYes

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Polychlorinated Biphenyls
Poisoning
Signs and Symptoms
Accidents
Peripheral Nervous System
Serum
Stretch Reflex
Abnormal Reflexes
Neurologic Examination
Peripheral Nervous System Diseases
Half-Life
Adipose Tissue
Health

All Science Journal Classification (ASJC) codes

  • Dermatology

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Neurological signs and symptoms in patients with chronic PCB poisoning (Yusho accident) for more than 36 years. / Furuya, Hirokazu; Yamada, Takeshi; Ohyagi, Yasumasa; Ikezoe, Koji; Miyoshi, Tasuku; Fujii, Naoki; Kira, Jun-Ichi.

In: Journal of Dermatological Science, Supplement, Vol. 1 SUPPL., No. 1, 01.04.2005.

Research output: Contribution to journalArticle

Furuya, Hirokazu ; Yamada, Takeshi ; Ohyagi, Yasumasa ; Ikezoe, Koji ; Miyoshi, Tasuku ; Fujii, Naoki ; Kira, Jun-Ichi. / Neurological signs and symptoms in patients with chronic PCB poisoning (Yusho accident) for more than 36 years. In: Journal of Dermatological Science, Supplement. 2005 ; Vol. 1 SUPPL., No. 1.
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