Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation

Takato Morioka, Shunji Nishio, Kei Hisada, Hiroshi Shigeto, Tomoya Yamamoto, Kiyotaka Fujii, Masashi Fukui

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Magnetoencephalographic (MEG) activities were recorded in five patients with cerebral arteriovenous malformation (AVM) who presented with epilepsy and no clinical history of intracranial hemorrhage, using a 37-channel DC superconducting quantum interference device (SQUID) system. While scalp-recorded electroencephalograms (EEG) failed to reveal paroxysmal discharge, MEGs demonstrated localized high frequency magnetic activity (HFMA). Magnetic source imaging (MSI) depicted the accumulation of equivalent current dipole (ECD) originating from HFMA around the nidus, and the ECD localization agreed well with spike localization on intraoperative electrocorticography (ECoG). These areas corresponded with the areas of hypoperfusion on single photon emission tomography and the intraoperative laser Doppler flow meter. We discussed the application of MEG in estimating interictal paroxysmal activity sources in patients with AVM and addressed the questions of its reliability and validity in source localization.

Original languageEnglish
Pages (from-to)206-212
Number of pages7
JournalNeurosurgical Review
Volume23
Issue number4
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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    Morioka, T., Nishio, S., Hisada, K., Shigeto, H., Yamamoto, T., Fujii, K., & Fukui, M. (2000). Neuromagnetic assessment of epileptogenicity in cerebral arteriovenous malformation. Neurosurgical Review, 23(4), 206-212. https://doi.org/10.1007/PL00011956