Neuropathic pain and ATP receptors in spinal microglia

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Neuropathic pain resulting from nerve injury or from diseases such as diabetes, HIV AIDS or cancer, that damage the peripheral nerves, can be agonizing, persistent over long periods, and, unfortunately, is often resistant to known pain-killers. The P2X receptors, of which seven subtypes (P2X 1-P2X7) have been cloned, are a family of ligand-gated cation channels activated by extracellular ATP and have important roles in regulating neuronal and glial functions in the nervous system. Recent advances in our understanding of the mechanisms underlying neuropathic pain have been made by defining important roles of P2X4 receptors and spinal microglia in the pathogenesis of neuropathic pain. Within the spinal dorsal horn, peripheral nerve injury leads to a progressive series of changes in microglia including morphological hypertrophy of the cell body and proliferation that are considered indicative of activation. Furthermore, P2X4 receptors that which are upregulated in activated microglia, have been found to be essential molecular mediators. The activation of P2X4 receptors releases brain-derived neurotrophic factor from microglia; this mediates the signaling from microglia to neurons, which in turn leads to pain hypersensitivity. We expect that understanding the key roles of these molecules in spinal microglia may lead to new strategies for the management of neuropathic pain.

Original languageEnglish
Pages (from-to)953-959
Number of pages7
JournalBrain and Nerve
Volume59
Issue number9
Publication statusPublished - Sep 2007

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Purinergic P2 Receptors
Nociceptors
Microglia
Neuralgia
Purinergic P2X4 Receptors
Ligand-Gated Ion Channels
Pain
Peripheral Nerve Injuries
Brain-Derived Neurotrophic Factor
Peripheral Nerves
Neuroglia
Hypertrophy
Nervous System
Cations
Hypersensitivity
Acquired Immunodeficiency Syndrome
Adenosine Triphosphate
Cell Proliferation
HIV
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Neuropathic pain and ATP receptors in spinal microglia. / Makoto, Tsuda; Inoue, Kazuhide.

In: Brain and Nerve, Vol. 59, No. 9, 09.2007, p. 953-959.

Research output: Contribution to journalReview article

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