Neuropathic pain and spinal microglia: A big problem from molecules in 'small' glia

Makoto Tsuda, Kazuhide Inoue, Michael W. Salter

Research output: Contribution to journalReview article

592 Citations (Scopus)

Abstract

Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. Such pain can be experienced after nerve injury or as part of diseases that affect peripheral nerve function, such as diabetes and AIDS; it can also be a component of pain in other conditions, such as cancer. Following peripheral nerve injury, microglia in the spinal cord become activated. Recent evidence indicates that activated microglia are key cellular intermediaries in the pathogenesis of nerve injury-induced pain hypersensitivity because P2X4 purinoceptors and p38 mitogen-activated protein kinase, which are present in activated microglia, are required molecular mediators. It is important to establish how these molecules are activated in spinal microglia following nerve injury and how they cause signaling to neurons in the dorsal horn pain transmission network. Answers to these questions could lead to new strategies that assist in the diagnosis and management of neuropathic pain - strategies not previously anticipated by a neuron-centric view of pain plasticity in the dorsal horn.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalTrends in Neurosciences
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 1 2005

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Microglia
Neuralgia
Neuroglia
Pain
Wounds and Injuries
Purinergic P2X4 Receptors
Posterior Horn Cells
Peripheral Nerve Injuries
Peripheral Nervous System Diseases
p38 Mitogen-Activated Protein Kinases
Spinal Cord
Hypersensitivity
Acquired Immunodeficiency Syndrome
Neurons
Neoplasms

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Neuropathic pain and spinal microglia : A big problem from molecules in 'small' glia. / Tsuda, Makoto; Inoue, Kazuhide; Salter, Michael W.

In: Trends in Neurosciences, Vol. 28, No. 2, 01.02.2005, p. 101-107.

Research output: Contribution to journalReview article

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