Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

A growing body of evidence indicates that extracellular ATP released or leaked from nonexcitable cells as well as neurons plays important roles in the regulation of neuronal and glial functions in the entire body through ATP receptors. ATP receptors (ionotropic P2X and metabotropic P2Y receptors) are the most abundant receptor families in living organisms. In the central nervous system, these receptors participate in the synaptic transmission and intercellular communications between neurons and glia. The glia cells are classified into three types: astrocytes; oligodendrocytes; and microglia. There are many reports that spinal microglia express ATP receptors (P2X4, P2X7, P2Y6, and P2Y12 receptors) that have very important roles. We reported that several molecules of microglia are activated after peripheral nerve injury in a neuropathic pain model. In particular, P2X4 receptors (P2X4Rs) expressed in microglia play a critical role in evoking neuropathic pain. P2X4Rs are upregulated in spinal microglia after nerve injury by several factors such as the CC chemokine receptor CCR2, fibronectin in the spinal cord, interferon regulatory factor (IRF) 8, and IRF5 expressed in microglia. The inhibition of P2X4R action suppresses the functions of microglia and neuropathic pain. These results indicate that overexpressing P2X4Rs on microglia are a central player in evoking neuropathic pain.

Original languageEnglish
Pages (from-to)563-569
Number of pages7
JournalYakugaku Zasshi
Volume137
Issue number5
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Microglia
Neuroglia
Pain
Purinergic P2X4 Receptors
Neuralgia
Purinergic P2 Receptors
CCR Receptors
Neurons
Peripheral Nerve Injuries
Oligodendroglia
Fibronectins
Synaptic Transmission
Astrocytes
Spinal Cord
Central Nervous System
Adenosine Triphosphate
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Neuropharmacological study of atp receptors, especially in the relationship between glia and pain. / Inoue, Kazuhide.

In: Yakugaku Zasshi, Vol. 137, No. 5, 01.01.2017, p. 563-569.

Research output: Contribution to journalReview article

@article{3df5547e52164d3db7a2bf80dcc00907,
title = "Neuropharmacological study of atp receptors, especially in the relationship between glia and pain",
abstract = "A growing body of evidence indicates that extracellular ATP released or leaked from nonexcitable cells as well as neurons plays important roles in the regulation of neuronal and glial functions in the entire body through ATP receptors. ATP receptors (ionotropic P2X and metabotropic P2Y receptors) are the most abundant receptor families in living organisms. In the central nervous system, these receptors participate in the synaptic transmission and intercellular communications between neurons and glia. The glia cells are classified into three types: astrocytes; oligodendrocytes; and microglia. There are many reports that spinal microglia express ATP receptors (P2X4, P2X7, P2Y6, and P2Y12 receptors) that have very important roles. We reported that several molecules of microglia are activated after peripheral nerve injury in a neuropathic pain model. In particular, P2X4 receptors (P2X4Rs) expressed in microglia play a critical role in evoking neuropathic pain. P2X4Rs are upregulated in spinal microglia after nerve injury by several factors such as the CC chemokine receptor CCR2, fibronectin in the spinal cord, interferon regulatory factor (IRF) 8, and IRF5 expressed in microglia. The inhibition of P2X4R action suppresses the functions of microglia and neuropathic pain. These results indicate that overexpressing P2X4Rs on microglia are a central player in evoking neuropathic pain.",
author = "Kazuhide Inoue",
year = "2017",
month = "1",
day = "1",
doi = "10.1248/yakushi.16-00262",
language = "English",
volume = "137",
pages = "563--569",
journal = "Yakugaku Zasshi",
issn = "0031-6903",
publisher = "公益社団法人 日本薬学会",
number = "5",

}

TY - JOUR

T1 - Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

AU - Inoue, Kazuhide

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A growing body of evidence indicates that extracellular ATP released or leaked from nonexcitable cells as well as neurons plays important roles in the regulation of neuronal and glial functions in the entire body through ATP receptors. ATP receptors (ionotropic P2X and metabotropic P2Y receptors) are the most abundant receptor families in living organisms. In the central nervous system, these receptors participate in the synaptic transmission and intercellular communications between neurons and glia. The glia cells are classified into three types: astrocytes; oligodendrocytes; and microglia. There are many reports that spinal microglia express ATP receptors (P2X4, P2X7, P2Y6, and P2Y12 receptors) that have very important roles. We reported that several molecules of microglia are activated after peripheral nerve injury in a neuropathic pain model. In particular, P2X4 receptors (P2X4Rs) expressed in microglia play a critical role in evoking neuropathic pain. P2X4Rs are upregulated in spinal microglia after nerve injury by several factors such as the CC chemokine receptor CCR2, fibronectin in the spinal cord, interferon regulatory factor (IRF) 8, and IRF5 expressed in microglia. The inhibition of P2X4R action suppresses the functions of microglia and neuropathic pain. These results indicate that overexpressing P2X4Rs on microglia are a central player in evoking neuropathic pain.

AB - A growing body of evidence indicates that extracellular ATP released or leaked from nonexcitable cells as well as neurons plays important roles in the regulation of neuronal and glial functions in the entire body through ATP receptors. ATP receptors (ionotropic P2X and metabotropic P2Y receptors) are the most abundant receptor families in living organisms. In the central nervous system, these receptors participate in the synaptic transmission and intercellular communications between neurons and glia. The glia cells are classified into three types: astrocytes; oligodendrocytes; and microglia. There are many reports that spinal microglia express ATP receptors (P2X4, P2X7, P2Y6, and P2Y12 receptors) that have very important roles. We reported that several molecules of microglia are activated after peripheral nerve injury in a neuropathic pain model. In particular, P2X4 receptors (P2X4Rs) expressed in microglia play a critical role in evoking neuropathic pain. P2X4Rs are upregulated in spinal microglia after nerve injury by several factors such as the CC chemokine receptor CCR2, fibronectin in the spinal cord, interferon regulatory factor (IRF) 8, and IRF5 expressed in microglia. The inhibition of P2X4R action suppresses the functions of microglia and neuropathic pain. These results indicate that overexpressing P2X4Rs on microglia are a central player in evoking neuropathic pain.

UR - http://www.scopus.com/inward/record.url?scp=85018434740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018434740&partnerID=8YFLogxK

U2 - 10.1248/yakushi.16-00262

DO - 10.1248/yakushi.16-00262

M3 - Review article

C2 - 28458288

AN - SCOPUS:85018434740

VL - 137

SP - 563

EP - 569

JO - Yakugaku Zasshi

JF - Yakugaku Zasshi

SN - 0031-6903

IS - 5

ER -