TY - JOUR
T1 - Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice
AU - Egashira, Nobuaki
AU - Hayakawa, Kazuhide
AU - Mishima, Kenichi
AU - Kimura, Hitomi
AU - Iwasaki, Katsunori
AU - Fujiwara, Michihiro
N1 - Funding Information:
This study was supported in part by the Advanced Materials Institute of Fukuoka University.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/6/3
Y1 - 2004/6/3
N2 - In the present study, we examined the neuroprotective effect of γ-glutamylethylamide (theanine) on the ischemic brain damage in a middle cerebral artery occlusion model in mice. Theanine was injected i.p. 3 h after the occlusion or immediately before and 3 h after the occlusion. Theanine (1 mg/kg) significantly decreased the size of the cerebral infarcts 1 day after the occlusion. In contrast, theanine did not affect the cerebral blood flow, brain temperature and physiological variables (pH, pCO2, pO2 and hematocrit) in this model. These results suggest that theanine directly provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction.
AB - In the present study, we examined the neuroprotective effect of γ-glutamylethylamide (theanine) on the ischemic brain damage in a middle cerebral artery occlusion model in mice. Theanine was injected i.p. 3 h after the occlusion or immediately before and 3 h after the occlusion. Theanine (1 mg/kg) significantly decreased the size of the cerebral infarcts 1 day after the occlusion. In contrast, theanine did not affect the cerebral blood flow, brain temperature and physiological variables (pH, pCO2, pO2 and hematocrit) in this model. These results suggest that theanine directly provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction.
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U2 - 10.1016/j.neulet.2004.03.046
DO - 10.1016/j.neulet.2004.03.046
M3 - Article
C2 - 15157996
AN - SCOPUS:2442592793
SN - 0304-3940
VL - 363
SP - 58
EP - 61
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -