Abstract
Citidine-5-diphosphocholine or citicoline (CDP-choline) is used as a neuroprotective and memory-enhancing drug in cerebral stroke, Alzheimer's disease, and other neurovascular diseases. Non-clinical studies have demonstrated the neuroprotective effects of CDP-choline in ischemic animal models. However, the relationship between the neuroprotective effect and the memory enhancing effect of CDP-choline is still unknown. No studies have demonstrated the ameliorative effect on impaired spatial memory and the suppressive effect on neuronal cell death of CDP-choline in the same model. In this study, we examined the effect of CDP-choline on impaired spatial memory and hippocampal CA1 neuronal death in rats subjected to repeated cerebral ischemia, and we compared the mechanism of CDP-choline to that of donepezil. Seven days post administration of CDP-choline (100, 300, 1000 mg/kg per day, p.o.) or donepezil increased correct choices and reduced error choices in an eight-arm radial maze task in a dose-dependent manner. Neuronal cell death of caspase-3 protein-positive neurons in the hippocampus were reduced by repeated administration of CDP-choline at the highest dose. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 232-237 |
| Number of pages | 6 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 116 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 24 2011 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
Cite this
Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia. / Takasaki, Kotaro; Uchida, Kanako; Fujikawa, Risako; Nogami, Ai; Nakamura, Kazuya; Kawasaki, Chihiro; Yamaguchi, Kazuko; Morita, Masahiko; Morishita, Koji; Kubota, Kaori; Katsurabayashi, Shutaro; Mishima, Kenichi; Fujiwara, Michihiro; Iwasaki, Katsunori.
In: Journal of Pharmacological Sciences, Vol. 116, No. 2, 24.06.2011, p. 232-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia
AU - Takasaki, Kotaro
AU - Uchida, Kanako
AU - Fujikawa, Risako
AU - Nogami, Ai
AU - Nakamura, Kazuya
AU - Kawasaki, Chihiro
AU - Yamaguchi, Kazuko
AU - Morita, Masahiko
AU - Morishita, Koji
AU - Kubota, Kaori
AU - Katsurabayashi, Shutaro
AU - Mishima, Kenichi
AU - Fujiwara, Michihiro
AU - Iwasaki, Katsunori
PY - 2011/6/24
Y1 - 2011/6/24
N2 - Citidine-5-diphosphocholine or citicoline (CDP-choline) is used as a neuroprotective and memory-enhancing drug in cerebral stroke, Alzheimer's disease, and other neurovascular diseases. Non-clinical studies have demonstrated the neuroprotective effects of CDP-choline in ischemic animal models. However, the relationship between the neuroprotective effect and the memory enhancing effect of CDP-choline is still unknown. No studies have demonstrated the ameliorative effect on impaired spatial memory and the suppressive effect on neuronal cell death of CDP-choline in the same model. In this study, we examined the effect of CDP-choline on impaired spatial memory and hippocampal CA1 neuronal death in rats subjected to repeated cerebral ischemia, and we compared the mechanism of CDP-choline to that of donepezil. Seven days post administration of CDP-choline (100, 300, 1000 mg/kg per day, p.o.) or donepezil increased correct choices and reduced error choices in an eight-arm radial maze task in a dose-dependent manner. Neuronal cell death of caspase-3 protein-positive neurons in the hippocampus were reduced by repeated administration of CDP-choline at the highest dose. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia.
AB - Citidine-5-diphosphocholine or citicoline (CDP-choline) is used as a neuroprotective and memory-enhancing drug in cerebral stroke, Alzheimer's disease, and other neurovascular diseases. Non-clinical studies have demonstrated the neuroprotective effects of CDP-choline in ischemic animal models. However, the relationship between the neuroprotective effect and the memory enhancing effect of CDP-choline is still unknown. No studies have demonstrated the ameliorative effect on impaired spatial memory and the suppressive effect on neuronal cell death of CDP-choline in the same model. In this study, we examined the effect of CDP-choline on impaired spatial memory and hippocampal CA1 neuronal death in rats subjected to repeated cerebral ischemia, and we compared the mechanism of CDP-choline to that of donepezil. Seven days post administration of CDP-choline (100, 300, 1000 mg/kg per day, p.o.) or donepezil increased correct choices and reduced error choices in an eight-arm radial maze task in a dose-dependent manner. Neuronal cell death of caspase-3 protein-positive neurons in the hippocampus were reduced by repeated administration of CDP-choline at the highest dose. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia.
UR - http://www.scopus.com/inward/record.url?scp=79959369914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959369914&partnerID=8YFLogxK
U2 - 10.1254/jphs.11013FP
DO - 10.1254/jphs.11013FP
M3 - Article
C2 - 21613753
AN - SCOPUS:79959369914
VL - 116
SP - 232
EP - 237
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 2
ER -