Abstract
In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.
| Original language | English |
|---|---|
| Pages (from-to) | 424-430 |
| Number of pages | 7 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 109 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 22 2009 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
Cite this
Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats. / Pu, Fengling; Motohashi, Kyoko; Kaneko, Tomohiro; Tanaka, Yurika; Manome, Naomi; Irie, Keiichi; Takata, Jirou; Egashira, Nobuaki; Oishi, Ryozo; Okamoto, Takuya; Sei, Yasuo; Yokozawa, Takako; Mishima, Kenichi; Iwasaki, Katsunori; Fujiwara, Michihiro.
In: Journal of Pharmacological Sciences, Vol. 109, No. 3, 22.06.2009, p. 424-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats
AU - Pu, Fengling
AU - Motohashi, Kyoko
AU - Kaneko, Tomohiro
AU - Tanaka, Yurika
AU - Manome, Naomi
AU - Irie, Keiichi
AU - Takata, Jirou
AU - Egashira, Nobuaki
AU - Oishi, Ryozo
AU - Okamoto, Takuya
AU - Sei, Yasuo
AU - Yokozawa, Takako
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Fujiwara, Michihiro
PY - 2009/6/22
Y1 - 2009/6/22
N2 - In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.
AB - In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.
UR - http://www.scopus.com/inward/record.url?scp=67249106879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67249106879&partnerID=8YFLogxK
U2 - 10.1254/jphs.08245FP
DO - 10.1254/jphs.08245FP
M3 - Article
VL - 109
SP - 424
EP - 430
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -