TY - JOUR
T1 - Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats
AU - Pu, Fengling
AU - Motohashi, Kyoko
AU - Kaneko, Tomohiro
AU - Tanaka, Yurika
AU - Manome, Naomi
AU - Irie, Keiichi
AU - Takata, Jirou
AU - Egashira, Nobuaki
AU - Oishi, Ryozo
AU - Okamoto, Takuya
AU - Sei, Yasuo
AU - Yokozawa, Takako
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Fujiwara, Michihiro
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.
AB - In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.
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U2 - 10.1254/jphs.08245FP
DO - 10.1254/jphs.08245FP
M3 - Article
C2 - 19276616
AN - SCOPUS:67249106879
SN - 1347-8613
VL - 109
SP - 424
EP - 430
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 3
ER -