Neuroscience of emotional memory and posttraumatic stress disorder

Shigenobu Kanba; Koutaro Kudo; Naoko Kaneko; Henny Wati; Hironobu Iguchi; Keiko Takemoto

doi:10.1007/4-431-29567-4_5

Neuroscience of emotional memory and posttraumatic stress disorder

Shigenobu Kanba, Koutaro Kudo, Naoko Kaneko, Henny Wati, Hironobu Iguchi, Keiko Takemoto

Internal Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Posttraumatic stress disorder (PTSD) is now widely recognized in Japan followingthe Kobe earthquake and the Tokyo subway sarin poisoning in 1995. Wider awarenessof this disorder has resulted in an increase in the number of patients presentingwith the core symptoms of PTSD, which include: (1) persistent increased arousal;(2) reexperience of a traumatic event; (3) persistent avoidance of stimuli associatedwith the trauma; and (4) numbing of general responsiveness.We have conducted studies to elucidate the biological mechanisms that causethese clinical symptoms and deeply engrain memories associated with highly emotionalevents (emotional memory). We used animal models to target a phenomenoncalled neurogenesis and the dynamics of a gene transcription factor called cyclicAMP-response element binding (CREB) protein in the hippocampus. This chapterdiscusses the results of some of our studies.

Original language	English
Title of host publication	PTSD
Subtitle of host publication	Brain Mechanisms and Clinical Implications
Publisher	Springer Japan
Pages	47-53
Number of pages	7
ISBN (Electronic)	9784431295679
ISBN (Print)	4431295666, 9784431295662
DOIs	https://doi.org/10.1007/4-431-29567-4_5
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Agricultural and Biological Sciences(all)
Medicine(all)
Neuroscience(all)

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10.1007/4-431-29567-4_5

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abstract = "Posttraumatic stress disorder (PTSD) is now widely recognized in Japan followingthe Kobe earthquake and the Tokyo subway sarin poisoning in 1995. Wider awarenessof this disorder has resulted in an increase in the number of patients presentingwith the core symptoms of PTSD, which include: (1) persistent increased arousal;(2) reexperience of a traumatic event; (3) persistent avoidance of stimuli associatedwith the trauma; and (4) numbing of general responsiveness.We have conducted studies to elucidate the biological mechanisms that causethese clinical symptoms and deeply engrain memories associated with highly emotionalevents (emotional memory). We used animal models to target a phenomenoncalled neurogenesis and the dynamics of a gene transcription factor called cyclicAMP-response element binding (CREB) protein in the hippocampus. This chapterdiscusses the results of some of our studies.",

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AU - Kanba, Shigenobu

AU - Kudo, Koutaro

AU - Kaneko, Naoko

AU - Wati, Henny

AU - Iguchi, Hironobu

AU - Takemoto, Keiko

PY - 2006

Y1 - 2006

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Neuroscience of emotional memory and posttraumatic stress disorder

Abstract

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