Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis

Yumi Mizuno, Hidetoshi Takada, Kyoko Urakami, Kenji Ihara, Ryutaro Kira, Aiko Suminoe, Shouichi Ohga, Tomonobu Aoki, Toshiro Hara

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Neurotrophin-3 levels were measured in the cerebrospinal fluid of 35 patients with bacterial meningitis, viral meningitis, or encephalitis by two- site enzyme immunoassay. Elevated cerebrospinal fluid levels of neurotrophin- 3 were demonstrated in 8 of 18 patients with bacterial meningitis. Follow-up examination of the eight patients at the convalescent stage showed diminished cerebrospinal fluid levels of neurotrophin-3. In contrast, none of the 17 patients with viral meningitis or encephalitis showed an elevation of neurotrophin-3 levels in cerebrospinal fluid. No relationships were observed between neurotrophin-3 levels and cerebrospinal fluid cell numbers, cerebrospinal fluid protein levels, serum C-reactive protein concentrations, or outcome in bacterial meningitis. Since neurotrophin-3 is involved in the survival of neurons and the modulation of the immune system, neurotrophin-3 could play a neuroprotective or immunomodulatory role in bacterial meningitis.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalJournal of Child Neurology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2000

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis'. Together they form a unique fingerprint.

Cite this