Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy

Takehiro Kawashiri, Nobuaki Egashira, Yoshinori Itoh, Takao Shimazoe, Yoko Ikegami, Takahisa Yano, Megumu Yoshimura, Ryozo Oishi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings.

Original languageEnglish
Pages (from-to)154-163
Number of pages10
JournalEuropean Journal of Cancer
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

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Paclitaxel
Neoplasms
Hyperalgesia
neurotropin
Vaccinia virus
Spinal Ganglia
Peripheral Nervous System Diseases
Sciatic Nerve
Tumor Cell Line
Microtubules
Rabbits
Skin
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. / Kawashiri, Takehiro; Egashira, Nobuaki; Itoh, Yoshinori; Shimazoe, Takao; Ikegami, Yoko; Yano, Takahisa; Yoshimura, Megumu; Oishi, Ryozo.

In: European Journal of Cancer, Vol. 45, No. 1, 01.01.2009, p. 154-163.

Research output: Contribution to journalArticle

Kawashiri, Takehiro ; Egashira, Nobuaki ; Itoh, Yoshinori ; Shimazoe, Takao ; Ikegami, Yoko ; Yano, Takahisa ; Yoshimura, Megumu ; Oishi, Ryozo. / Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. In: European Journal of Cancer. 2009 ; Vol. 45, No. 1. pp. 154-163.
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