Abstract
Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings.
| Original language | English |
|---|---|
| Pages (from-to) | 154-163 |
| Number of pages | 10 |
| Journal | European Journal of Cancer |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2009 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy. / Kawashiri, Takehiro; Egashira, Nobuaki; Itoh, Yoshinori; Shimazoe, Takao; Ikegami, Yoko; Yano, Takahisa; Yoshimura, Megumu; Oishi, Ryozo.
In: European Journal of Cancer, Vol. 45, No. 1, 01.01.2009, p. 154-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy
AU - Kawashiri, Takehiro
AU - Egashira, Nobuaki
AU - Itoh, Yoshinori
AU - Shimazoe, Takao
AU - Ikegami, Yoko
AU - Yano, Takahisa
AU - Yoshimura, Megumu
AU - Oishi, Ryozo
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings.
AB - Paclitaxel is a commonly used anticancer drug, but it frequently causes peripheral neuropathy. Neurotropin, a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic painful conditions. In the present study, we investigated the effect of neurotropin on the paclitaxel-induced neuropathy in rats. Repeated administration of paclitaxel induced mechanical allodynia, cold hyperalgesia, and motor dysfunction. These neuropathies were mostly reversed by the repeated administration of neurotropin. Furthermore, neurotropin ameliorated the paclitaxel-induced axonal degeneration in cultured PC12 and rat dorsal root ganglion cells, and in rat sciatic nerve. In addition, neurotropin did not affect the microtubule aggregation or anti-tumour effect induced by paclitaxel in the tumour cell lines or tumour cells-implanted mice. These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings.
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UR - http://www.scopus.com/inward/citedby.url?scp=57649178652&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2008.10.004
DO - 10.1016/j.ejca.2008.10.004
M3 - Article
C2 - 19027286
AN - SCOPUS:57649178652
VL - 45
SP - 154
EP - 163
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
SN - 0959-8049
IS - 1
ER -