Neurovascular coupling in the human somatosensory cortex: A single trial study

Mitsuru Kikuchi, Kiyomi Shitamichi, Sanae Ueno, Yuko Yoshimura, Gerard B. Remijn, Kikuko Nagao, Toshio Munesue, Koichi Iiyama, Tsunehisa Tsubokawa, Yasuhiro Haruta, Yoshihiro Inoue, Katsumi Watanabe, Takanori Hashimoto, Haruhiro Higashida, Yoshio Minabe

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Oscillations in the higher frequency range are closely related to regional brain hemodynamic changes. Here we investigated this neurovascular coupling in humans in response to electrical stimulation of the right median nerve. In a single-trial study, we simultaneously recorded hemodynamic fluctuations in the somatosensory cortex by near infrared spectroscopy and brain neuronal oscillations by whole-head magnetoencephalography (MEG). The results from six volunteers showed that neural fluctuations at β or γ-band power were correlated with hemodynamic fluctuation during stimulus conditions. These correlations were prominent with a time delay of 5-7 s. This study provides new direct evidence that hemodynamic onset lags specific neural oscillations in the order of seconds in human awake conditions using noninvasive methods.

    Original languageEnglish
    Pages (from-to)1106-1110
    Number of pages5
    JournalNeuroReport
    Volume21
    Issue number17
    DOIs
    Publication statusPublished - Dec 8 2010

    All Science Journal Classification (ASJC) codes

    • Neuroscience(all)

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