TY - JOUR
T1 - Neutralization of transforming growth factor (Tgf)-β1 activity reduced fibrosis and enhanced regeneration of glycerol-injured rat muscle
AU - Mahdy, Mohamed A.A.
AU - Warita, Katsuhiko
AU - Hosaka, Yoshinao Z.
N1 - Funding Information:
ACKNOWLEDGMENTS. This work was supported by JSPS KAKENHI Grant Number 16H02585. The first author acknowledges the Egyptian Government for financial support.
Publisher Copyright:
© 2020 The Japanese Society of Veterinary Science.
PY - 2020
Y1 - 2020
N2 - Recently, we have shown that glycerol induces early fibrosis in rat muscles which persists up to two weeks after injury. The current study aims to determine the possible factor associated with fibrosis of rat muscle following glycerol injury. Eight-week-old male Wistar rats received either glycerol only (as a control) or a co-treatment of neutralizing antibody to transforming growth factor (TGF)-β1 (5 and 12.5 µg). Both antibody doses significantly decreased fibrosis and improved muscle regeneration suggesting that anti-TGF-β1 antibody has both anti-fibrotic and myogenic effects. In conclusion, fibrosis developed in glycerol-injured rat muscles, might be mediated, in part, by the upregulation of TGF-β1 expression. Targeting TGF-β1 could be a promising approach for inhibiting fibrosis and enhancing muscle regeneration.
AB - Recently, we have shown that glycerol induces early fibrosis in rat muscles which persists up to two weeks after injury. The current study aims to determine the possible factor associated with fibrosis of rat muscle following glycerol injury. Eight-week-old male Wistar rats received either glycerol only (as a control) or a co-treatment of neutralizing antibody to transforming growth factor (TGF)-β1 (5 and 12.5 µg). Both antibody doses significantly decreased fibrosis and improved muscle regeneration suggesting that anti-TGF-β1 antibody has both anti-fibrotic and myogenic effects. In conclusion, fibrosis developed in glycerol-injured rat muscles, might be mediated, in part, by the upregulation of TGF-β1 expression. Targeting TGF-β1 could be a promising approach for inhibiting fibrosis and enhancing muscle regeneration.
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U2 - 10.1292/jvms.19-0446
DO - 10.1292/jvms.19-0446
M3 - Comment/debate
C2 - 31875598
AN - SCOPUS:85079623512
SN - 0916-7250
VL - 82
SP - 168
EP - 171
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
IS - 2
ER -