Abstract
Purpose: As cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed the mortality hazard ratios (HRs), including the preoperative NLR, obtained from data for 283 ESCC patients undergoing resection in the period from 2005 to 2011, adjusting for clinical and pathological features. Results: A high NLR was associated with a significantly shorter overall survival (p = 0.0018) and cancer-specific survival (p = 0.0097). In the multivariate Cox model, we confirmed that the NLR was an independent prognostic marker for both overall survival (p = 0.0081) and cancer-specific survival (p = 0.028). The outcomes were not significantly modified by other diagnostic factors, including the tumor stage, in the survival analysis. Conclusions: The preoperative NLR is significantly associated with a poor prognosis in patients with ESCC, suggesting the utility of NLR as a cost-effective and broadly available independent prognostic marker of ESCC.
| Original language | English |
|---|---|
| Pages (from-to) | 405-413 |
| Number of pages | 9 |
| Journal | Surgery today |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2016 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients. / Kosumi, Keisuke; Baba, Yoshifumi; Ishimoto, Takatsugu; Harada, Kazuto; Nakamura, Kenichi; Ohuchi, Mayuko; Kiyozumi, Yuki; Izumi, Daisuke; Tokunaga, Ryuma; Taki, Katsunobu; Higashi, Takaaki; Miyata, Tatsunori; Kurashige, Junji; Hiyoshi, Yukiharu; Iwagami, Shiro; Sakamoto, Yasuo; Miyamoto, Yuji; Yoshida, Naoya; Watanabe, Masayuki; Baba, Hideo.
In: Surgery today, Vol. 46, No. 4, 01.04.2016, p. 405-413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients
AU - Kosumi, Keisuke
AU - Baba, Yoshifumi
AU - Ishimoto, Takatsugu
AU - Harada, Kazuto
AU - Nakamura, Kenichi
AU - Ohuchi, Mayuko
AU - Kiyozumi, Yuki
AU - Izumi, Daisuke
AU - Tokunaga, Ryuma
AU - Taki, Katsunobu
AU - Higashi, Takaaki
AU - Miyata, Tatsunori
AU - Kurashige, Junji
AU - Hiyoshi, Yukiharu
AU - Iwagami, Shiro
AU - Sakamoto, Yasuo
AU - Miyamoto, Yuji
AU - Yoshida, Naoya
AU - Watanabe, Masayuki
AU - Baba, Hideo
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose: As cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed the mortality hazard ratios (HRs), including the preoperative NLR, obtained from data for 283 ESCC patients undergoing resection in the period from 2005 to 2011, adjusting for clinical and pathological features. Results: A high NLR was associated with a significantly shorter overall survival (p = 0.0018) and cancer-specific survival (p = 0.0097). In the multivariate Cox model, we confirmed that the NLR was an independent prognostic marker for both overall survival (p = 0.0081) and cancer-specific survival (p = 0.028). The outcomes were not significantly modified by other diagnostic factors, including the tumor stage, in the survival analysis. Conclusions: The preoperative NLR is significantly associated with a poor prognosis in patients with ESCC, suggesting the utility of NLR as a cost-effective and broadly available independent prognostic marker of ESCC.
AB - Purpose: As cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed the mortality hazard ratios (HRs), including the preoperative NLR, obtained from data for 283 ESCC patients undergoing resection in the period from 2005 to 2011, adjusting for clinical and pathological features. Results: A high NLR was associated with a significantly shorter overall survival (p = 0.0018) and cancer-specific survival (p = 0.0097). In the multivariate Cox model, we confirmed that the NLR was an independent prognostic marker for both overall survival (p = 0.0081) and cancer-specific survival (p = 0.028). The outcomes were not significantly modified by other diagnostic factors, including the tumor stage, in the survival analysis. Conclusions: The preoperative NLR is significantly associated with a poor prognosis in patients with ESCC, suggesting the utility of NLR as a cost-effective and broadly available independent prognostic marker of ESCC.
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U2 - 10.1007/s00595-015-1197-0
DO - 10.1007/s00595-015-1197-0
M3 - Article
AN - SCOPUS:84959172336
VL - 46
SP - 405
EP - 413
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 4
ER -