Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients

Keisuke Kosumi, Yoshifumi Baba, Takatsugu Ishimoto, Kazuto Harada, Kenichi Nakamura, Mayuko Ohuchi, Yuki Kiyozumi, Daisuke Izumi, Ryuma Tokunaga, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Junji Kurashige, Yukiharu Hiyoshi, Shiro Iwagami, Yasuo Sakamoto, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: As cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed the mortality hazard ratios (HRs), including the preoperative NLR, obtained from data for 283 ESCC patients undergoing resection in the period from 2005 to 2011, adjusting for clinical and pathological features. Results: A high NLR was associated with a significantly shorter overall survival (p = 0.0018) and cancer-specific survival (p = 0.0097). In the multivariate Cox model, we confirmed that the NLR was an independent prognostic marker for both overall survival (p = 0.0081) and cancer-specific survival (p = 0.028). The outcomes were not significantly modified by other diagnostic factors, including the tumor stage, in the survival analysis. Conclusions: The preoperative NLR is significantly associated with a poor prognosis in patients with ESCC, suggesting the utility of NLR as a cost-effective and broadly available independent prognostic marker of ESCC.

Original languageEnglish
Pages (from-to)405-413
Number of pages9
JournalSurgery today
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

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Neutrophils
Lymphocytes
Survival
Neoplasms
Survival Analysis
Esophageal Squamous Cell Carcinoma
Proportional Hazards Models
Leukocytes
Costs and Cost Analysis
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Kosumi, K., Baba, Y., Ishimoto, T., Harada, K., Nakamura, K., Ohuchi, M., ... Baba, H. (2016). Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients. Surgery today, 46(4), 405-413. https://doi.org/10.1007/s00595-015-1197-0

Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients. / Kosumi, Keisuke; Baba, Yoshifumi; Ishimoto, Takatsugu; Harada, Kazuto; Nakamura, Kenichi; Ohuchi, Mayuko; Kiyozumi, Yuki; Izumi, Daisuke; Tokunaga, Ryuma; Taki, Katsunobu; Higashi, Takaaki; Miyata, Tatsunori; Kurashige, Junji; Hiyoshi, Yukiharu; Iwagami, Shiro; Sakamoto, Yasuo; Miyamoto, Yuji; Yoshida, Naoya; Watanabe, Masayuki; Baba, Hideo.

In: Surgery today, Vol. 46, No. 4, 01.04.2016, p. 405-413.

Research output: Contribution to journalArticle

Kosumi, K, Baba, Y, Ishimoto, T, Harada, K, Nakamura, K, Ohuchi, M, Kiyozumi, Y, Izumi, D, Tokunaga, R, Taki, K, Higashi, T, Miyata, T, Kurashige, J, Hiyoshi, Y, Iwagami, S, Sakamoto, Y, Miyamoto, Y, Yoshida, N, Watanabe, M & Baba, H 2016, 'Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients', Surgery today, vol. 46, no. 4, pp. 405-413. https://doi.org/10.1007/s00595-015-1197-0
Kosumi, Keisuke ; Baba, Yoshifumi ; Ishimoto, Takatsugu ; Harada, Kazuto ; Nakamura, Kenichi ; Ohuchi, Mayuko ; Kiyozumi, Yuki ; Izumi, Daisuke ; Tokunaga, Ryuma ; Taki, Katsunobu ; Higashi, Takaaki ; Miyata, Tatsunori ; Kurashige, Junji ; Hiyoshi, Yukiharu ; Iwagami, Shiro ; Sakamoto, Yasuo ; Miyamoto, Yuji ; Yoshida, Naoya ; Watanabe, Masayuki ; Baba, Hideo. / Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients. In: Surgery today. 2016 ; Vol. 46, No. 4. pp. 405-413.
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abstract = "Purpose: As cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed the mortality hazard ratios (HRs), including the preoperative NLR, obtained from data for 283 ESCC patients undergoing resection in the period from 2005 to 2011, adjusting for clinical and pathological features. Results: A high NLR was associated with a significantly shorter overall survival (p = 0.0018) and cancer-specific survival (p = 0.0097). In the multivariate Cox model, we confirmed that the NLR was an independent prognostic marker for both overall survival (p = 0.0081) and cancer-specific survival (p = 0.028). The outcomes were not significantly modified by other diagnostic factors, including the tumor stage, in the survival analysis. Conclusions: The preoperative NLR is significantly associated with a poor prognosis in patients with ESCC, suggesting the utility of NLR as a cost-effective and broadly available independent prognostic marker of ESCC.",
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AU - Kosumi, Keisuke

AU - Baba, Yoshifumi

AU - Ishimoto, Takatsugu

AU - Harada, Kazuto

AU - Nakamura, Kenichi

AU - Ohuchi, Mayuko

AU - Kiyozumi, Yuki

AU - Izumi, Daisuke

AU - Tokunaga, Ryuma

AU - Taki, Katsunobu

AU - Higashi, Takaaki

AU - Miyata, Tatsunori

AU - Kurashige, Junji

AU - Hiyoshi, Yukiharu

AU - Iwagami, Shiro

AU - Sakamoto, Yasuo

AU - Miyamoto, Yuji

AU - Yoshida, Naoya

AU - Watanabe, Masayuki

AU - Baba, Hideo

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N2 - Purpose: As cancer advances, changes in the systemic inflammatory response alter the relative levels of circulating white blood cell types and may contribute to the progression and outcomes of cancer. The aim of the current study is to clarify the impact of the preoperative neutrophil/lymphocyte ratio (NLR) on the prognosis and whether clinical and pathological features modify the influence of the NLR on the prognosis of esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed the mortality hazard ratios (HRs), including the preoperative NLR, obtained from data for 283 ESCC patients undergoing resection in the period from 2005 to 2011, adjusting for clinical and pathological features. Results: A high NLR was associated with a significantly shorter overall survival (p = 0.0018) and cancer-specific survival (p = 0.0097). In the multivariate Cox model, we confirmed that the NLR was an independent prognostic marker for both overall survival (p = 0.0081) and cancer-specific survival (p = 0.028). The outcomes were not significantly modified by other diagnostic factors, including the tumor stage, in the survival analysis. Conclusions: The preoperative NLR is significantly associated with a poor prognosis in patients with ESCC, suggesting the utility of NLR as a cost-effective and broadly available independent prognostic marker of ESCC.

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