New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation

Ghezala Gaidi, Tomofumi Miyamoto, Véronique Laurens, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Three new acylated triterpene saponins 1-3, with a quillaic acid as aglycon, were isolated from the roots of Silene fortunei together with a known phytoecdysteroid (20-hydroxyecdysone). The compounds were characterized mainly by a combination of 2D NMR techniques, mass spectrometry, and chemical methods. Saponins 1-3, jenisseensosides C and D (4, 5), and 6 (deacylated form of 2/3 and 4/5) were found to stimulate the proliferation of the Jurkat tumor cell lines at low concentration. At high concentration, 2/3 and 4/5 inhibited the proliferation of the cells and suggested the induction of apoptosis.

Original languageEnglish
Pages (from-to)1568-1572
Number of pages5
JournalJournal of Natural Products
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 1 2002

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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