[New approaches to target leukemia stem cells]

Katsuto Takenaka, Koichi Akashi

Research output: Contribution to journalArticle

Abstract

Human acute myeloid leukemia is organized as a hierarchy initiated and maintained by "leukemia stem cells(LSC)" which possesses self-renewal capacity. LSCs are therapeutic targets and must be eliminated to cure the patients. Recent advances in LSC research provided insights into the cell surface antigens preferentially expressed on AML-LSCs compared with normal hematopoietic stem cells and the signaling pathways defining the LSC characteristics. These molecules are potential targets to eradicate LSCs. Especially, monoclonal antibodies targeting surface antigens expressed on LSCs, including CD123, CD44, TIM-3 and CD47 have been shown its efficacy against AML-LSCs in xenotransplant models.

Original languageEnglish
Pages (from-to)1018-1025
Number of pages8
JournalNihon rinsho. Japanese journal of clinical medicine
Volume72
Issue number6
Publication statusPublished - Jun 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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