Abstract
To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
| Original language | English |
|---|---|
| Title of host publication | Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease |
| Editors | Inga Neumann, Rainer Landgraf |
| Pages | 79-90 |
| Number of pages | 12 |
| DOIs | |
| Publication status | Published - Jul 24 2008 |
Publication series
| Name | Progress in Brain Research |
|---|---|
| Volume | 170 |
| ISSN (Print) | 0079-6123 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
New aspects of oxytocin receptor function revealed by knockout mice : sociosexual behaviour and control of energy balance. / Nishimori, Katsuhiko; Takayanagi, Yuki; Yoshida, Masahide; Kasahara, Yoshiyuki; Young, Larry J.; Kawamata, Masaki.
Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease. ed. / Inga Neumann; Rainer Landgraf. 2008. p. 79-90 (Progress in Brain Research; Vol. 170).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - New aspects of oxytocin receptor function revealed by knockout mice
T2 - sociosexual behaviour and control of energy balance
AU - Nishimori, Katsuhiko
AU - Takayanagi, Yuki
AU - Yoshida, Masahide
AU - Kasahara, Yoshiyuki
AU - Young, Larry J.
AU - Kawamata, Masaki
PY - 2008/7/24
Y1 - 2008/7/24
N2 - To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
AB - To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
UR - http://www.scopus.com/inward/record.url?scp=47549116536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47549116536&partnerID=8YFLogxK
U2 - 10.1016/S0079-6123(08)00408-1
DO - 10.1016/S0079-6123(08)00408-1
M3 - Chapter
C2 - 18655874
AN - SCOPUS:47549116536
SN - 9780444532015
T3 - Progress in Brain Research
SP - 79
EP - 90
BT - Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease
A2 - Neumann, Inga
A2 - Landgraf, Rainer
ER -