New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

Katsuhiko Nishimori; Yuki Takayanagi; Masahide Yoshida; Yoshiyuki Kasahara; Larry J. Young; Masaki Kawamata

doi:10.1016/S0079-6123(08)00408-1

New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

Katsuhiko Nishimori, Yuki Takayanagi, Masahide Yoshida, Yoshiyuki Kasahara, Larry J. Young, Masaki Kawamata

Research output: Chapter in Book/Report/Conference proceeding › Chapter

66 Citations (Scopus)

Abstract

To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.

Original language	English
Title of host publication	Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease
Editors	Inga Neumann, Rainer Landgraf
Pages	79-90
Number of pages	12
DOIs	https://doi.org/10.1016/S0079-6123(08)00408-1
Publication status	Published - 2008
Externally published	Yes

Publication series

Name	Progress in Brain Research
Volume	170
ISSN (Print)	0079-6123

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Access to Document

10.1016/S0079-6123(08)00408-1

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Nishimori, K., Takayanagi, Y., Yoshida, M., Kasahara, Y., Young, L. J., & Kawamata, M. (2008). New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance. In I. Neumann, & R. Landgraf (Eds.), Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease (pp. 79-90). (Progress in Brain Research; Vol. 170). https://doi.org/10.1016/S0079-6123(08)00408-1

New aspects of oxytocin receptor function revealed by knockout mice : sociosexual behaviour and control of energy balance. / Nishimori, Katsuhiko; Takayanagi, Yuki; Yoshida, Masahide; Kasahara, Yoshiyuki; Young, Larry J.; Kawamata, Masaki.

Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease. ed. / Inga Neumann; Rainer Landgraf. 2008. p. 79-90 (Progress in Brain Research; Vol. 170).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Nishimori, K, Takayanagi, Y, Yoshida, M, Kasahara, Y, Young, LJ & Kawamata, M 2008, New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance. in I Neumann & R Landgraf (eds), Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease. Progress in Brain Research, vol. 170, pp. 79-90. https://doi.org/10.1016/S0079-6123(08)00408-1

Nishimori K, Takayanagi Y, Yoshida M, Kasahara Y, Young LJ, Kawamata M. New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance. In Neumann I, Landgraf R, editors, Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease. 2008. p. 79-90. (Progress in Brain Research). https://doi.org/10.1016/S0079-6123(08)00408-1

Nishimori, Katsuhiko ; Takayanagi, Yuki ; Yoshida, Masahide ; Kasahara, Yoshiyuki ; Young, Larry J. ; Kawamata, Masaki. / New aspects of oxytocin receptor function revealed by knockout mice : sociosexual behaviour and control of energy balance. Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease. editor / Inga Neumann ; Rainer Landgraf. 2008. pp. 79-90 (Progress in Brain Research).

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abstract = "To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.",

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