New CR system with pixel size of 50μm for digital mammography: Physical imaging properties and detection of subtle microcalcifications

Purpose: To investigate the physical imaging properties and detection of simulated microcalcifications of a new computed radiography (CR) system with a pixel size of 50μm for digital mammography. Materials and Methods: New and conventional CR were employed in this study. The new CR system included a high-resolution imaging plate coupled with the FCR5000MA (50μm pixel pitch) including transparent support and a dual-sided reader. The conventional CR system was coupled with the FCR9000 (100μm pixel pitch). Modulation transfer functions (MTFs) and Wiener spectra (WS) of the new and conventional CR systems were measured. Observer performance tests were conducted to compare the effects of pixel size (50μm vs. 100μm) on the diagnostic accuracy of CR systems in the detection of simulated microcalcifications. Results: The presampling MTF of the new CR system was higher at high frequencies than the conventional CR system. The WS of the new CR system was comparable to that of the conventional CR system at all frequencies. The area under the receiver operating characteristic (ROC) curve (Az) obtained with the new CR and the conventional CR systems were 0.84 and 0.79, respectively. Results showed that the detection of simulated clustered microcalcifications was significantly improved by use of the new CR system compared with the conventional CR system (p<0.05). Conclusion: The new CR mammography system improved physical imaging properties and detection of simulated microcalcifications over conventional CR mammography.