New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi

Yhiya M. Amen; Qinchang Zhu; Mohamed S. Afifi; Ahmed F. Halim; Ahmed Ashour; Kuniyoshi Shimizu

doi:10.1016/j.phytol.2016.07.024

New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi

Yhiya M. Amen, Qinchang Zhu, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu

Sustainable Bioresources Science

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16 Citations (Scopus)

Abstract

Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against five human cancer cell lines (MCF-7, HeLa, HCT-116, Caco-2 and HepG2) and two normal human cell lines (TIG-1 and HF19). Results showed that the new compounds have a strong to moderate selective cytotoxic activity against MCF-7 while they showed moderate to weak activity against HeLa cell line. Potent cytotoxic activities of some of the known isolated compounds are reported for the first time.

Original language	English
Pages (from-to)	64-70
Number of pages	7
Journal	Phytochemistry Letters
Volume	17
DOIs	https://doi.org/10.1016/j.phytol.2016.07.024
Publication status	Published - Sept 1 2016

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2016.07.024

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title = "New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi",

abstract = "Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against five human cancer cell lines (MCF-7, HeLa, HCT-116, Caco-2 and HepG2) and two normal human cell lines (TIG-1 and HF19). Results showed that the new compounds have a strong to moderate selective cytotoxic activity against MCF-7 while they showed moderate to weak activity against HeLa cell line. Potent cytotoxic activities of some of the known isolated compounds are reported for the first time.",

author = "Amen, {Yhiya M.} and Qinchang Zhu and Afifi, {Mohamed S.} and Halim, {Ahmed F.} and Ahmed Ashour and Kuniyoshi Shimizu",

note = "Funding Information: The Egyptian Government is acknowledged for the fellowship support to Yhiya M. Amen. We would like to express our gratitude to Prof. Tomofumi Miyamoto, graduate school of pharmaceutical sciences, Kyushu University, Japan, for carrying out the optical rotation measurement. We would like to thank Research and Education Support Center of the faculty of Agriculture, Kyushu University for supporting facilities for ESI-IT-TOF analysis. This work was performed under the Cooperative Research Program of ⿿Network Joint Research Center for Materials and Devices⿿, Kyushu University. This work was supported by KAKENHI Grant Numbers 26660147 and 26304047 . Publisher Copyright: {\textcopyright} 2016 Phytochemical Society of Europe",

year = "2016",

month = sep,

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doi = "10.1016/j.phytol.2016.07.024",

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T1 - New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi

AU - Amen, Yhiya M.

AU - Zhu, Qinchang

AU - Afifi, Mohamed S.

AU - Halim, Ahmed F.

AU - Ashour, Ahmed

AU - Shimizu, Kuniyoshi

N1 - Funding Information: The Egyptian Government is acknowledged for the fellowship support to Yhiya M. Amen. We would like to express our gratitude to Prof. Tomofumi Miyamoto, graduate school of pharmaceutical sciences, Kyushu University, Japan, for carrying out the optical rotation measurement. We would like to thank Research and Education Support Center of the faculty of Agriculture, Kyushu University for supporting facilities for ESI-IT-TOF analysis. This work was performed under the Cooperative Research Program of ⿿Network Joint Research Center for Materials and Devices⿿, Kyushu University. This work was supported by KAKENHI Grant Numbers 26660147 and 26304047 . Publisher Copyright: © 2016 Phytochemical Society of Europe

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against five human cancer cell lines (MCF-7, HeLa, HCT-116, Caco-2 and HepG2) and two normal human cell lines (TIG-1 and HF19). Results showed that the new compounds have a strong to moderate selective cytotoxic activity against MCF-7 while they showed moderate to weak activity against HeLa cell line. Potent cytotoxic activities of some of the known isolated compounds are reported for the first time.

AB - Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against five human cancer cell lines (MCF-7, HeLa, HCT-116, Caco-2 and HepG2) and two normal human cell lines (TIG-1 and HF19). Results showed that the new compounds have a strong to moderate selective cytotoxic activity against MCF-7 while they showed moderate to weak activity against HeLa cell line. Potent cytotoxic activities of some of the known isolated compounds are reported for the first time.

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New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi

Abstract

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