New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi

Yhiya M. Amen, Qinchang Zhu, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Further chemical investigation of the metabolites in the fruiting bodies of Ganoderma lingzhi resulted in isolation of eight triterpenes; two of them are new triterpene acid ethyl esters. Their structures were established based on spectroscopic studies and comparison with the known related compounds. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against five human cancer cell lines (MCF-7, HeLa, HCT-116, Caco-2 and HepG2) and two normal human cell lines (TIG-1 and HF19). Results showed that the new compounds have a strong to moderate selective cytotoxic activity against MCF-7 while they showed moderate to weak activity against HeLa cell line. Potent cytotoxic activities of some of the known isolated compounds are reported for the first time.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalPhytochemistry Letters
Volume17
DOIs
Publication statusPublished - Sep 1 2016

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Ganoderma
Reishi
Triterpenes
triterpenoids
Cells
cell lines
triterpene acids
Cell Line
human cell lines
fruiting bodies
esters
metabolites
Metabolites
HeLa Cells
Assays
Esters
assays
Acids
lanostanoid
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

Cite this

New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi. / Amen, Yhiya M.; Zhu, Qinchang; Afifi, Mohamed S.; Halim, Ahmed F.; Ashour, Ahmed; Shimizu, Kuniyoshi.

In: Phytochemistry Letters, Vol. 17, 01.09.2016, p. 64-70.

Research output: Contribution to journalArticle

Amen, Yhiya M. ; Zhu, Qinchang ; Afifi, Mohamed S. ; Halim, Ahmed F. ; Ashour, Ahmed ; Shimizu, Kuniyoshi. / New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi. In: Phytochemistry Letters. 2016 ; Vol. 17. pp. 64-70.
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