TY - JOUR
T1 - New cytotoxic spongian diterpenes from the sponge Dysidea cf. arenaria
AU - Agena, Mika
AU - Tanaka, Chiaki
AU - Hanif, Novriyandi
AU - Yasumoto-Hirose, Mina
AU - Tanaka, Junichi
N1 - Funding Information:
This research was supported in part by the 21st Century COE program from University of the Ryukyus, Grant-in-Aids (Nos. 16550145 and 18032061) from MEXT, Japan, and PharmaMar. We are indebted to Prof. D. Uemura, currently at Keio University, for allowing us to use a mass spectrometer and to Dr. J. N. A. Hooper, acting director, Queensland Museum, South Brisbane, QLD, Australia, for the identification of the sponge. We thank Ms. S. Kato for help on collection of the sponge.
PY - 2009/2/14
Y1 - 2009/2/14
N2 - Seven new (1-7) and three known (8-10) spongian-class diterpenes have been isolated from the sponge Dysidea cf. arenaria collected in Okinawa. Compound 6 was also isolated from the nudibranch Chromodoris kuniei. The structures of the new entities were elucidated by spectroscopic analyses. Three of the new spongians (2, 6, and 7) showed cytotoxicity against NBT-T2 rat bladder epithelial cells.
AB - Seven new (1-7) and three known (8-10) spongian-class diterpenes have been isolated from the sponge Dysidea cf. arenaria collected in Okinawa. Compound 6 was also isolated from the nudibranch Chromodoris kuniei. The structures of the new entities were elucidated by spectroscopic analyses. Three of the new spongians (2, 6, and 7) showed cytotoxicity against NBT-T2 rat bladder epithelial cells.
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U2 - 10.1016/j.tet.2008.11.101
DO - 10.1016/j.tet.2008.11.101
M3 - Article
AN - SCOPUS:58149334791
SN - 0040-4020
VL - 65
SP - 1495
EP - 1499
JO - Tetrahedron
JF - Tetrahedron
IS - 7
ER -