New DNA binding ligands as a model of chromomycin A 3

Shuhei Imoto, Yoshinari Haruta, Kyouichi Watanabe, Shigeki Sasaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this study, new DNA-binding ligands were designed to mimic Chromomycin A 3 (CRA 3), which contains a hydroxylated tetrahydroanthracene chromophore substituted with di and trisaccharides. The trisaccharide part of CRA 3 that is supposed to contribute to form the Mg 2+-coordinated dimer was expected to be mimicked by a simple alkyl group attached to the chromophore part as new model compounds. The present study has successfully demonstrated that the new ligands form Mg 2+-coordinated dimer complexes to exhibit DNA-binding affinity.

Original languageEnglish
Pages (from-to)4855-4859
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number19
DOIs
Publication statusPublished - Oct 4 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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