New halogenated C15 acetogenins from Okinawan sea hare Aplysia dactylomela

Koushi Matsuyama, Tomoe Inoue, Tomoki Muroga, Naomichi Arima, Matsumi Doe, Fumito Tani, Yuka Ookawa, Yuuka Okamoto, Satoaki Onitsuka, Hiroaki Okamura, Tetsuo Iwagawa, Toshiyuki Hamada

Research output: Contribution to journalArticlepeer-review

Abstract

Two new C15 acetogenins 1 and 2, along with four known sesquiterpenes isolaurenisol (3), laurokamurene D (4), itomanol (5), and acetylelatol (6), were isolated from sea hare Aplysia dactylomela. The structures, including the relative stereochemistries, of 1 and 2 were determined based on spectroscopic evidence. Finally, the in vitro cytotoxicities of the six compounds against S1T cells, an adult T-cell leukemia cell line, were evaluated.

Original languageEnglish
Article number132889
JournalTetrahedron
DOIs
Publication statusAccepted/In press - 2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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