TY - JOUR
T1 - New Insights into Measles Virus Brain Infections
AU - Watanabe, Shumpei
AU - Shirogane, Yuta
AU - Sato, Yuma
AU - Hashiguchi, Takao
AU - Yanagi, Yusuke
N1 - Funding Information:
We thank S. Ohno for invaluable discussions. This study was supported by the grants from the Ministry of Education, Culture, Sports, Science, and Technology ( KAKENHI 24115005 ), the Takeda Science Foundation , and Japan Agency for Medical Research and Development ( JP17fm0208022h , JP18fm0208022h , JP18fk0108001j ).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/2
Y1 - 2019/2
N2 - Measles virus (MeV) may persist in the brain, causing fatal neurodegenerative diseases, subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However, the mechanism of MeV propagation in the brain remains unexplained because human neurons affected by the diseases do not express the known receptors for MeV. Recent studies have revealed that certain changes in the ectodomain of the MeV fusion (F) protein play a key role in MeV spread in the brain. These changes destabilize the prefusion form of the F protein and render it hyperfusogenic, which in turn allows the virus to propagate in neurons. Based on crystal structures of the F protein, effective fusion inhibitors could be developed to treat these diseases.
AB - Measles virus (MeV) may persist in the brain, causing fatal neurodegenerative diseases, subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However, the mechanism of MeV propagation in the brain remains unexplained because human neurons affected by the diseases do not express the known receptors for MeV. Recent studies have revealed that certain changes in the ectodomain of the MeV fusion (F) protein play a key role in MeV spread in the brain. These changes destabilize the prefusion form of the F protein and render it hyperfusogenic, which in turn allows the virus to propagate in neurons. Based on crystal structures of the F protein, effective fusion inhibitors could be developed to treat these diseases.
UR - http://www.scopus.com/inward/record.url?scp=85053156529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053156529&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2018.08.010
DO - 10.1016/j.tim.2018.08.010
M3 - Review article
C2 - 30220445
AN - SCOPUS:85053156529
SN - 0966-842X
VL - 27
SP - 164
EP - 175
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 2
ER -
