New insights on glucosylated lipids: Metabolism and functions

Yohei Ishibashi, Ayako Kohyama-Koganeya, Yoshio Hirabayashi

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)

Abstract

Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer), cholesterylglucoside (ChlGlc), and phosphatidylglucoside (PtdGlc), respectively. Glucosylation dramatically changes the functional properties of lipids. For instance, ceramide acts as a strong tumor suppressor that causes apoptosis and cell cycle arrest, while GlcCer has an opposite effect, downregulating ceramide activities. All glucosylated lipids are enriched in lipid rafts or microdomains and play fundamental roles in a variety of cellular processes. In this review, we discuss the biological functions and metabolism of these three glucosylated lipids.

Original languageEnglish
Pages (from-to)1475-1485
Number of pages11
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1831
Issue number9
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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