New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus

Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu

Research output: Contribution to journal › Article

Abstract

Two new isoindolin-1-ones, named erinacerin (M–N) along with eleven known compounds have been isolated from the fruiting bodies of the medicinal mushroom Hericium erinaceus. The structures of compounds were elucidated based on spectroscopic studies and comparison with the known related ones. The anticancer potential of the isolates were tested with an in vitro cytotoxic assay against six human cancer cell lines (SH-SY5Y, 1321N1, HCT-116, Caco-2, OVK18 and HeLa).

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalPhytochemistry Letters
Volume32
DOIs
Publication statusPublished - Aug 1 2019

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Hericium
Mushroom Bodies
Erinaceus
fruiting bodies
Fungi
Assays
Cells
cell lines
Cell Line
fungi
assays
Neoplasms
neoplasm cells
medicinal fungi
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

Cite this

New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus. / Ashour, Ahmed; Amen, Yhiya; Allam, Ahmed E.; Kudo, Takashi; Nagata, Maki; Ohnuki, Koichiro; Shimizu, Kuniyoshi.

In: Phytochemistry Letters, Vol. 32, 01.08.2019, p. 10-14.

Research output: Contribution to journal › Article

Ashour, A, Amen, Y, Allam, AE, Kudo, T, Nagata, M, Ohnuki, K & Shimizu, K 2019, 'New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus', Phytochemistry Letters, vol. 32, pp. 10-14. https://doi.org/10.1016/j.phytol.2019.04.017
Ashour A, Amen Y, Allam AE, Kudo T, Nagata M, Ohnuki K et al. New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus. Phytochemistry Letters. 2019 Aug 1;32:10-14. https://doi.org/10.1016/j.phytol.2019.04.017
Ashour, Ahmed ; Amen, Yhiya ; Allam, Ahmed E. ; Kudo, Takashi ; Nagata, Maki ; Ohnuki, Koichiro ; Shimizu, Kuniyoshi. / New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus. In: Phytochemistry Letters. 2019 ; Vol. 32. pp. 10-14.
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