New method for assessing liver fibrosis based on acoustic radiation force impulse: A special reference to the difference between right and left liver

Takeo Toshima, Ken Shirabe, kazuki takeishi, Takashi Motomura, Yohei Mano, Hideaki Uchiyama, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.

Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalJournal of gastroenterology
Volume46
Issue number5
DOIs
Publication statusPublished - May 1 2011

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Touch
Acoustics
Liver Cirrhosis
Radiation
Liver
Elasticity Imaging Techniques
Fibrosis
Biomarkers
Collagen Type IV
Hyaluronic Acid
Aspartate Aminotransferases
ROC Curve
Liver Diseases
Healthy Volunteers
Chronic Disease
Blood Platelets

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

New method for assessing liver fibrosis based on acoustic radiation force impulse : A special reference to the difference between right and left liver. / Toshima, Takeo; Shirabe, Ken; takeishi, kazuki; Motomura, Takashi; Mano, Yohei; Uchiyama, Hideaki; Yoshizumi, Tomoharu; Soejima, Yuji; Taketomi, Akinobu; Maehara, Yoshihiko.

In: Journal of gastroenterology, Vol. 46, No. 5, 01.05.2011, p. 705-711.

Research output: Contribution to journalArticle

Toshima, Takeo ; Shirabe, Ken ; takeishi, kazuki ; Motomura, Takashi ; Mano, Yohei ; Uchiyama, Hideaki ; Yoshizumi, Tomoharu ; Soejima, Yuji ; Taketomi, Akinobu ; Maehara, Yoshihiko. / New method for assessing liver fibrosis based on acoustic radiation force impulse : A special reference to the difference between right and left liver. In: Journal of gastroenterology. 2011 ; Vol. 46, No. 5. pp. 705-711.
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AU - Motomura, Takashi

AU - Mano, Yohei

AU - Uchiyama, Hideaki

AU - Yoshizumi, Tomoharu

AU - Soejima, Yuji

AU - Taketomi, Akinobu

AU - Maehara, Yoshihiko

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N2 - Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.

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