New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Hiroshi Furuno, Eunsang Kwon, Hiroyuki Momma, Desi Harneti, Rani Maharani, Unang Supratman, Ken ichi Kimura, Yoshihito Shiono

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Abstract

Five polyketides, paralactonic acids A-E (1–5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1–5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalFitoterapia
Volume132
DOIs
Publication statusPublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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    Suzuki, T., Ariefta, N. R., Koseki, T., Furuno, H., Kwon, E., Momma, H., Harneti, D., Maharani, R., Supratman, U., Kimura, K. I., & Shiono, Y. (2019). New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes. Fitoterapia, 132, 75-81. https://doi.org/10.1016/j.fitote.2018.11.017