New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons

Tadahiro Kin, Yasuki Nagai, Nobuyuki Iwamoto, Futoshi Minato, Osamu Iwamoto, Yuichi Hatsukawa, Mariko Segawa, Hideo Harada, Chikara Konno, Kentaro Ochiai, Kosuke Takakura

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26 Citations (Scopus)

Abstract

We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from natC(d,n) with 40MeV 5mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p) 67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.

Original languageEnglish
Article number034201
Journaljournal of the physical society of japan
Volume82
Issue number3
DOIs
Publication statusPublished - Mar 1 2013

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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    Kin, T., Nagai, Y., Iwamoto, N., Minato, F., Iwamoto, O., Hatsukawa, Y., Segawa, M., Harada, H., Konno, C., Ochiai, K., & Takakura, K. (2013). New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons. journal of the physical society of japan, 82(3), [034201]. https://doi.org/10.7566/JPSJ.82.034201