New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons

Tadahiro Kin, Yasuki Nagai, Nobuyuki Iwamoto, Futoshi Minato, Osamu Iwamoto, Yuichi Hatsukawa, Mariko Segawa, Hideo Harada, Chikara Konno, Kentaro Ochiai, Kosuke Takakura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from natC(d,n) with 40MeV 5mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p) 67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.

Original languageEnglish
Article number034201
Journaljournal of the physical society of japan
Volume82
Issue number3
DOIs
Publication statusPublished - Mar 1 2013

Fingerprint

fast neutrons
accelerators
isotopes
routes
neutrons
irradiation
cross sections
radioactive isotopes
deuterons
zinc
activation
impurities

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Kin, T., Nagai, Y., Iwamoto, N., Minato, F., Iwamoto, O., Hatsukawa, Y., ... Takakura, K. (2013). New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons. journal of the physical society of japan, 82(3), [034201]. https://doi.org/10.7566/JPSJ.82.034201

New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons. / Kin, Tadahiro; Nagai, Yasuki; Iwamoto, Nobuyuki; Minato, Futoshi; Iwamoto, Osamu; Hatsukawa, Yuichi; Segawa, Mariko; Harada, Hideo; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke.

In: journal of the physical society of japan, Vol. 82, No. 3, 034201, 01.03.2013.

Research output: Contribution to journalArticle

Kin, T, Nagai, Y, Iwamoto, N, Minato, F, Iwamoto, O, Hatsukawa, Y, Segawa, M, Harada, H, Konno, C, Ochiai, K & Takakura, K 2013, 'New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons', journal of the physical society of japan, vol. 82, no. 3, 034201. https://doi.org/10.7566/JPSJ.82.034201
Kin, Tadahiro ; Nagai, Yasuki ; Iwamoto, Nobuyuki ; Minato, Futoshi ; Iwamoto, Osamu ; Hatsukawa, Yuichi ; Segawa, Mariko ; Harada, Hideo ; Konno, Chikara ; Ochiai, Kentaro ; Takakura, Kosuke. / New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons. In: journal of the physical society of japan. 2013 ; Vol. 82, No. 3.
@article{ccfe29c3b02d492cb3caa8c08b22da22,
title = "New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons",
abstract = "We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from natC(d,n) with 40MeV 5mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p) 67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.",
author = "Tadahiro Kin and Yasuki Nagai and Nobuyuki Iwamoto and Futoshi Minato and Osamu Iwamoto and Yuichi Hatsukawa and Mariko Segawa and Hideo Harada and Chikara Konno and Kentaro Ochiai and Kosuke Takakura",
year = "2013",
month = "3",
day = "1",
doi = "10.7566/JPSJ.82.034201",
language = "English",
volume = "82",
journal = "Journal of the Physical Society of Japan",
issn = "0031-9015",
publisher = "Physical Society of Japan",
number = "3",

}

TY - JOUR

T1 - New production routes for medical isotopes 64Cu and 67Cu using accelerator neutrons

AU - Kin, Tadahiro

AU - Nagai, Yasuki

AU - Iwamoto, Nobuyuki

AU - Minato, Futoshi

AU - Iwamoto, Osamu

AU - Hatsukawa, Yuichi

AU - Segawa, Mariko

AU - Harada, Hideo

AU - Konno, Chikara

AU - Ochiai, Kentaro

AU - Takakura, Kosuke

PY - 2013/3/1

Y1 - 2013/3/1

N2 - We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from natC(d,n) with 40MeV 5mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p) 67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.

AB - We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from natC(d,n) with 40MeV 5mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p) 67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.

UR - http://www.scopus.com/inward/record.url?scp=84874696586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874696586&partnerID=8YFLogxK

U2 - 10.7566/JPSJ.82.034201

DO - 10.7566/JPSJ.82.034201

M3 - Article

AN - SCOPUS:84874696586

VL - 82

JO - Journal of the Physical Society of Japan

JF - Journal of the Physical Society of Japan

SN - 0031-9015

IS - 3

M1 - 034201

ER -