New therapeutic strategy for cancer targeting the hedgehog signaling pathway

Masafumi Nakamura, Makoto Kubo, Shuntaro Nagai, Koji Yamaguchi, Masao Tanaka, Mitsuo Katano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The hedgehog (Hh) signaling pathway was originally found as an organizer in embryonic development. The pathway is now implicated in the development of various tumors. Recently, it has been reported that the pathway activation is resulted from aberrant expression of the ligand, Sonic Hh (Shh), in pancreatic cancer and breast cancer. Here we developed a new strategy to control the activation of the Hh signaling pathway in cancer cells, which have ectopic and ligand dependent activation of the Hh signaling pathway. Our strategy may contribute to the development of a new cancer treatment.

Original languageEnglish
Pages (from-to)1914-1916
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume34
Issue number12
Publication statusPublished - Nov 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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