New triterpenoid estersaponins from the root barks of Pittosporum verticillatum subsp. verticillatum and evaluation of cytotoxicities

Mahenina Jaovita Manase, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The phytochemical investigation of the root barks of Pittosporum verticillatum Bojer subsp. verticillatum led to the isolation of three new triterpene saponins, 3-O-[β-d-glucopyranosyl-(1 → 2)]-[α-l- arabinopyranosyl-(1 → 3)]-[α-l-arabinofuranosyl-(1 → 4)]-β-d-glucuronopyranosyl-21-O-(2-acetoxy-2-methylbutanoyl)-R1-barrigenol (1), 3-O-[β-d-glucopyranosyl-(1 → 2)]-[α-l-arabinopyranosyl-(1 → 3)]-[α-l-arabinofuranosyl-(1 → 4)]-β-d- glucuronopyranosyl-21-O-(2-acetoxy-2-methylbutanoyl)-28-O-acetyl-R1-barrigenol (2), 3-O-[β-d-glucopyranosyl-(1 → 2)]-[α-l-arabinopyranosyl-(1 → 3)]-[α-l-arabinofuranosyl-(1 → 4)]-β-d- glucuronopyranosyl-21-O-β,β-dimethylacryloyl-22-O-angeloyl-R1- barrigenol (3), and one known saponin senaciapittoside B (4). Their structures were elucidated mainly by 1D- and 2D-NMR spectroscopy and HRESIMS. Compounds 1-4 were evaluated for their cytotoxicity against one human cancer cell line (SW480) and one rat cardiomyoblast cell line (H9c2).

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalFitoterapia
Volume91
DOIs
Publication statusPublished - Oct 21 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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