Nickel-catalyzed formation of a carbon-nitrogen bond at the β position of saturated ketones

Satoshi Ueno, Ryosuke Shimizu, Ryoichi Kuwano

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Gone fishing: When propiophenone and related ethyl ketones are treated with morpholine in the presence of K3PO4, chlorobenzene, and [Ni(cod)2]/PMe3 catalyst, a carbon-nitrogen bond is formed selectively at the β position (see scheme; cod=cycloocta-1,5-diene). Secondary amines were employed as substrates to give the corresponding β- enaminones.

Original languageEnglish
Pages (from-to)4543-4545
Number of pages3
JournalAngewandte Chemie - International Edition
Volume48
Issue number25
DOIs
Publication statusPublished - Jun 8 2009

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Catalysis

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