Nigerooligosaccharides augments natural killer activity of hepatic mononuclear cells in mice

Shinji Murosaki, Koutarou Muroyama, Yoshihiro Yamamoto, Tiei Liu, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)


    Nigerooligosaccharides (NOS), a mixture of nigerose and nigerosylmaltooligosaccharides, is immunopotentiating oligosaccharides found in foodstuffs. Augmentation of natural killer (NK) activity by NOS was studied in vitro and in vivo in mice. In vitro treatment of hepatic mononuclear cells (MNC) from normal mice with 1 μg/ml NOS 17 h or just prior to the cytotoxicity assay enhanced their cytotoxicity against YAC-1 cells. NK activity of hepatic MNC was also enhanced in mice injected intraperitoneally with 0.4 mg NOS or in mice given 1% NOS solution orally as a drinking fluid. In association with the augmentation of NK activity, increase in the liver weight induced by intravenous inoculation of EL-4 tumor cells was significantly suppressed by intraperitoneal pretreatment with 0.4 mg NOS. Moreover, drinking 1% NOS significantly improved the survival curve of mice intravenously inoculated with EL-4 cells. Our results suggest that the immunopotentiating activity of NOS is exerted partly through the augmentation of NK activity.

    Original languageEnglish
    Pages (from-to)151-159
    Number of pages9
    JournalInternational Immunopharmacology
    Issue number1
    Publication statusPublished - Jan 1 2002

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Pharmacology


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