Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats

Katsunori Iwasaki, Nobuaki Egashira, Yuki Takagaki, Yoshitaka Yoshimitsu, Izzettin Hatip-Al-Khatib, Kenichi Mishima, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and β-amyloid (Aβ). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD).

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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