Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Matthew R. Dreher; Martyna Elas; Kazuhiro Ichikawa; Eugene D. Barth; Ashutosh Chilkoti; Gerald M. Rosen; Howard J. Halpern; Mark Dewhirst

doi:10.1118/1.1782677

Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Matthew R. Dreher, Martyna Elas, Kazuhiro Ichikawa, Eugene D. Barth, Ashutosh Chilkoti, Gerald M. Rosen, Howard J. Halpern, Mark Dewhirst

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

Original language	English
Pages (from-to)	2755-2762
Number of pages	8
Journal	Medical physics
Volume	31
Issue number	10
DOIs	https://doi.org/10.1118/1.1782677
Publication status	Published - Oct 2004

All Science Journal Classification (ASJC) codes

Biophysics
Radiology Nuclear Medicine and imaging

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Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. / Dreher, Matthew R.; Elas, Martyna; Ichikawa, Kazuhiro; Barth, Eugene D.; Chilkoti, Ashutosh; Rosen, Gerald M.; Halpern, Howard J.; Dewhirst, Mark.

In: Medical physics, Vol. 31, No. 10, 10.2004, p. 2755-2762.

Research output: Contribution to journal › Article › peer-review

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abstract = "Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.",

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AU - Dreher, Matthew R.

AU - Elas, Martyna

AU - Ichikawa, Kazuhiro

AU - Barth, Eugene D.

AU - Chilkoti, Ashutosh

AU - Rosen, Gerald M.

AU - Halpern, Howard J.

AU - Dewhirst, Mark

PY - 2004/10

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N2 - Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

AB - Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

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Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Abstract

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