Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Matthew R. Dreher, Martyna Elas, Kazuhiro Ichikawa, Eugene D. Barth, Ashutosh Chilkoti, Gerald M. Rosen, Howard J. Halpern, Mark Dewhirst

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18 Citations (Scopus)

Abstract

Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

Original languageEnglish
Pages (from-to)2755-2762
Number of pages8
JournalMedical physics
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2004

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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    Dreher, M. R., Elas, M., Ichikawa, K., Barth, E. D., Chilkoti, A., Rosen, G. M., Halpern, H. J., & Dewhirst, M. (2004). Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Medical physics, 31(10), 2755-2762. https://doi.org/10.1118/1.1782677