Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Matthew R. Dreher; Martyna Elas; Kazuhiro Ichikawa; Eugene D. Barth; Ashutosh Chilkoti; Gerald M. Rosen; Howard J. Halpern; Mark Dewhirst

doi:10.1118/1.1782677

Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Matthew R. Dreher, Martyna Elas, Kazuhiro Ichikawa, Eugene D. Barth, Ashutosh Chilkoti, Gerald M. Rosen, Howard J. Halpern, Mark Dewhirst

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

Original language	English
Pages (from-to)	2755-2762
Number of pages	8
Journal	Medical physics
Volume	31
Issue number	10
DOIs	https://doi.org/10.1118/1.1782677
Publication status	Published - Oct 2004

All Science Journal Classification (ASJC) codes

Biophysics
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1118/1.1782677

Cite this

Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. / Dreher, Matthew R.; Elas, Martyna; Ichikawa, Kazuhiro; Barth, Eugene D.; Chilkoti, Ashutosh; Rosen, Gerald M.; Halpern, Howard J.; Dewhirst, Mark.

In: Medical physics, Vol. 31, No. 10, 10.2004, p. 2755-2762.

Research output: Contribution to journal › Article › peer-review

@article{f5d50d1a444c4ca78c8c0281c74ca46a,

title = "Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry",

abstract = "Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.",

author = "Dreher, {Matthew R.} and Martyna Elas and Kazuhiro Ichikawa and Barth, {Eugene D.} and Ashutosh Chilkoti and Rosen, {Gerald M.} and Halpern, {Howard J.} and Mark Dewhirst",

year = "2004",

month = oct,

doi = "10.1118/1.1782677",

language = "English",

volume = "31",

pages = "2755--2762",

journal = "Medical Physics",

issn = "0094-2405",

publisher = "AAPM - American Association of Physicists in Medicine",

number = "10",

}

TY - JOUR

T1 - Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

AU - Dreher, Matthew R.

AU - Elas, Martyna

AU - Ichikawa, Kazuhiro

AU - Barth, Eugene D.

AU - Chilkoti, Ashutosh

AU - Rosen, Gerald M.

AU - Halpern, Howard J.

AU - Dewhirst, Mark

PY - 2004/10

Y1 - 2004/10

N2 - Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

AB - Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

UR - http://www.scopus.com/inward/record.url?scp=7244255853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7244255853&partnerID=8YFLogxK

U2 - 10.1118/1.1782677

DO - 10.1118/1.1782677

M3 - Article

C2 - 15543780

AN - SCOPUS:7244255853

VL - 31

SP - 2755

EP - 2762

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 10

ER -

Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this