Abstract
Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is ∼0.3°C (80 μM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.
Original language | English |
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Pages (from-to) | 2755-2762 |
Number of pages | 8 |
Journal | Medical physics |
Volume | 31 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2004 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Radiology Nuclear Medicine and imaging