NKG2D-mediated tumor recognition and cancer immunotherapy

Takashi Morisaki; Hiroto Tanaka; Akifumi Kiyota; Norihiro Koya; Hideya Onishi; Akio Yamasaki; Hiroyuki Suzuki; Masafumi Nakamura; Mitsuo Katano

NKG2D-mediated tumor recognition and cancer immunotherapy

Takashi Morisaki, Hiroto Tanaka, Akifumi Kiyota, Norihiro Koya, Hideya Onishi, Akio Yamasaki, Hiroyuki Suzuki, Masafumi Nakamura, Mitsuo Katano

Research output: Contribution to journal › Article › peer-review

Abstract

The activating receptor natural killer group 2, member D (NKG2D) and its ligands play an important role in the NK, gamma/delta T cell, and CD8 ⁺ T cell-mediated immune response to tumors. We examined the ratio and intensity of NKG2D expression before and after stimulation with IL-2 and OKT3 in ex vivo expanded lymphocytes from 29 patients who had received adoptive immunotherapy. We demonstrated that NKG2D expression rate and intensity of lymphocytes significantly increased after stimulation, and that the magnitude of NKG2D expression by activated lymphocytes was significantly correlated with prognosis. Thus, the magnitude of NKG2D expression by activated lymphocytes may correlate with the quality of clinical-grade cytotoxic T lymphocytes.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Biotherapy
Volume	24
Issue number	1
Publication status	Published - Jan 2010

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The activating receptor natural killer group 2, member D (NKG2D) and its ligands play an important role in the NK, gamma/delta T cell, and CD8 + T cell-mediated immune response to tumors. We examined the ratio and intensity of NKG2D expression before and after stimulation with IL-2 and OKT3 in ex vivo expanded lymphocytes from 29 patients who had received adoptive immunotherapy. We demonstrated that NKG2D expression rate and intensity of lymphocytes significantly increased after stimulation, and that the magnitude of NKG2D expression by activated lymphocytes was significantly correlated with prognosis. Thus, the magnitude of NKG2D expression by activated lymphocytes may correlate with the quality of clinical-grade cytotoxic T lymphocytes.",

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AU - Morisaki, Takashi

AU - Tanaka, Hiroto

AU - Kiyota, Akifumi

AU - Koya, Norihiro

AU - Onishi, Hideya

AU - Yamasaki, Akio

AU - Suzuki, Hiroyuki

AU - Nakamura, Masafumi

AU - Katano, Mitsuo

PY - 2010/1

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N2 - The activating receptor natural killer group 2, member D (NKG2D) and its ligands play an important role in the NK, gamma/delta T cell, and CD8 + T cell-mediated immune response to tumors. We examined the ratio and intensity of NKG2D expression before and after stimulation with IL-2 and OKT3 in ex vivo expanded lymphocytes from 29 patients who had received adoptive immunotherapy. We demonstrated that NKG2D expression rate and intensity of lymphocytes significantly increased after stimulation, and that the magnitude of NKG2D expression by activated lymphocytes was significantly correlated with prognosis. Thus, the magnitude of NKG2D expression by activated lymphocytes may correlate with the quality of clinical-grade cytotoxic T lymphocytes.

AB - The activating receptor natural killer group 2, member D (NKG2D) and its ligands play an important role in the NK, gamma/delta T cell, and CD8 + T cell-mediated immune response to tumors. We examined the ratio and intensity of NKG2D expression before and after stimulation with IL-2 and OKT3 in ex vivo expanded lymphocytes from 29 patients who had received adoptive immunotherapy. We demonstrated that NKG2D expression rate and intensity of lymphocytes significantly increased after stimulation, and that the magnitude of NKG2D expression by activated lymphocytes was significantly correlated with prognosis. Thus, the magnitude of NKG2D expression by activated lymphocytes may correlate with the quality of clinical-grade cytotoxic T lymphocytes.

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NKG2D-mediated tumor recognition and cancer immunotherapy

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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