NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one

Kazuya Yoshiizumi, Fumio Nakajima, Takao Kiyoi, Hirosato Kondo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2463-2466
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number21
DOIs
Publication statusPublished - Nov 6 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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