NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one

Kazuya Yoshiizumi; Fumio Nakajima; Takao Kiyoi; Hirosato Kondo

doi:10.1016/S0960-894X(00)00490-X

NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one

Kazuya Yoshiizumi, Fumio Nakajima, Takao Kiyoi, Hirosato Kondo

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2463-2466
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	21
DOIs	https://doi.org/10.1016/S0960-894X(00)00490-X
Publication status	Published - Nov 6 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00490-X

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AU - Yoshiizumi, Kazuya

AU - Nakajima, Fumio

AU - Kiyoi, Takao

AU - Kondo, Hirosato

PY - 2000/11/6

Y1 - 2000/11/6

N2 - In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2. (C) 2000 Elsevier Science Ltd.

AB - In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2. (C) 2000 Elsevier Science Ltd.

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ER -

NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one

Abstract

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