Abstract
A 61-year-old man consulted a nearby doctor with the chief complaint of lassitude in June 2010. Blood tests revealed a hemoglobin level of 37 g/dL The observation of significant anemia resulted in a full medical workup. On computed tomography (CT) findings a large mass (17×10 cm in diameter) was found in the abdominal region. The lumen was distended with accumulation of air and fluid. In addition, I continued with a bladder wall, but did not recognize the abnormality that was apparent to a bladder lumen. There was no evidence of ileus. A diagnosis of appendix cancer or sarcoma was made preoperatively. During surgery, the bladder was observed to have some permeation, but the bladder wall contained a lesion of small intestinal origin with only slight permeation. The neighboring small intestine was surrounded by the tumor, with 3 sites of Penetration. Histopathologic diagnosis indicated a high-risk gastrointestinal stromal tumor (GIST) with mitotic figures (44/50 high power fields) In accordance with the recommended guidelines, imatinib was administered for 1 year. Two sites of recurrences were observed by CT after discontinuing imatinib. A second operation was performed without increase because of the absence other lesions Separate lesions in the sigmoid colon and jejunum were removed surgically. The tumor in the sigmoid colon was a lesion with high denaturation for mesenchymal system tumor such as GISTs by pathologic diagnosis. The lesion in the small mesentery was a suture granuloma. In this case, the combination of surgical management with chemotherapy resulted in good quality of life with no recurrence despite the presence of a high-risk GIST.
| Original language | English |
|---|---|
| Pages (from-to) | 2475-2477 |
| Number of pages | 3 |
| Journal | Japanese Journal of Cancer and Chemotherapy |
| Volume | 41 |
| Issue number | 12 |
| Publication status | Published - Nov 2014 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
No recurrent case of the combination of surgical management with chemotherapy. / Hasegawa, Hirofumi; Harada, Akira; Kitagawa, Dai; Nakamura, Toshihiko; Kondo, Naoko; Shoji, Fumihiro; Kabashima, Akira; Teramoto, Seiichi; Funahashi, Wataru; Ikeda, Youichi.
In: Japanese Journal of Cancer and Chemotherapy, Vol. 41, No. 12, 11.2014, p. 2475-2477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No recurrent case of the combination of surgical management with chemotherapy
AU - Hasegawa, Hirofumi
AU - Harada, Akira
AU - Kitagawa, Dai
AU - Nakamura, Toshihiko
AU - Kondo, Naoko
AU - Shoji, Fumihiro
AU - Kabashima, Akira
AU - Teramoto, Seiichi
AU - Funahashi, Wataru
AU - Ikeda, Youichi
PY - 2014/11
Y1 - 2014/11
N2 - A 61-year-old man consulted a nearby doctor with the chief complaint of lassitude in June 2010. Blood tests revealed a hemoglobin level of 37 g/dL The observation of significant anemia resulted in a full medical workup. On computed tomography (CT) findings a large mass (17×10 cm in diameter) was found in the abdominal region. The lumen was distended with accumulation of air and fluid. In addition, I continued with a bladder wall, but did not recognize the abnormality that was apparent to a bladder lumen. There was no evidence of ileus. A diagnosis of appendix cancer or sarcoma was made preoperatively. During surgery, the bladder was observed to have some permeation, but the bladder wall contained a lesion of small intestinal origin with only slight permeation. The neighboring small intestine was surrounded by the tumor, with 3 sites of Penetration. Histopathologic diagnosis indicated a high-risk gastrointestinal stromal tumor (GIST) with mitotic figures (44/50 high power fields) In accordance with the recommended guidelines, imatinib was administered for 1 year. Two sites of recurrences were observed by CT after discontinuing imatinib. A second operation was performed without increase because of the absence other lesions Separate lesions in the sigmoid colon and jejunum were removed surgically. The tumor in the sigmoid colon was a lesion with high denaturation for mesenchymal system tumor such as GISTs by pathologic diagnosis. The lesion in the small mesentery was a suture granuloma. In this case, the combination of surgical management with chemotherapy resulted in good quality of life with no recurrence despite the presence of a high-risk GIST.
AB - A 61-year-old man consulted a nearby doctor with the chief complaint of lassitude in June 2010. Blood tests revealed a hemoglobin level of 37 g/dL The observation of significant anemia resulted in a full medical workup. On computed tomography (CT) findings a large mass (17×10 cm in diameter) was found in the abdominal region. The lumen was distended with accumulation of air and fluid. In addition, I continued with a bladder wall, but did not recognize the abnormality that was apparent to a bladder lumen. There was no evidence of ileus. A diagnosis of appendix cancer or sarcoma was made preoperatively. During surgery, the bladder was observed to have some permeation, but the bladder wall contained a lesion of small intestinal origin with only slight permeation. The neighboring small intestine was surrounded by the tumor, with 3 sites of Penetration. Histopathologic diagnosis indicated a high-risk gastrointestinal stromal tumor (GIST) with mitotic figures (44/50 high power fields) In accordance with the recommended guidelines, imatinib was administered for 1 year. Two sites of recurrences were observed by CT after discontinuing imatinib. A second operation was performed without increase because of the absence other lesions Separate lesions in the sigmoid colon and jejunum were removed surgically. The tumor in the sigmoid colon was a lesion with high denaturation for mesenchymal system tumor such as GISTs by pathologic diagnosis. The lesion in the small mesentery was a suture granuloma. In this case, the combination of surgical management with chemotherapy resulted in good quality of life with no recurrence despite the presence of a high-risk GIST.
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UR - http://www.scopus.com/inward/citedby.url?scp=84949227112&partnerID=8YFLogxK
M3 - Article
C2 - 25731562
AN - SCOPUS:84949227112
VL - 41
SP - 2475
EP - 2477
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 12
ER -