Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Masamichi Yamamoto, Yukio Saijoh, Altana Perea-Gomez, William Shawiot, Richard R. Behringer, Siew Lan Ang, Hiroshi Hamada, Chikara Meno

Research output: Contribution to journalArticlepeer-review

202 Citations (Scopus)

Abstract

Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalNature
Volume428
Issue number6981
DOIs
Publication statusPublished - Mar 25 2004

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo'. Together they form a unique fingerprint.

Cite this