Nogo receptor 1 is expressed in both primary cultured glial cells and neurons

Junichi Ukai, Shiro Imagama, Tomohiro Ohgomori, Zenya Ito, Kei Ando, Naoki Ishiguro, Kenji Kadomatsu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Nogo receptor (NgR) is common in myelin-derived molecules, i.e., Nogo, MAG, and OMgp, and plays important roles in both axon fasciculation and the inhibition of axonal regeneration. In contrast to NgR's roles in neurons, its roles in glial cells have been poorly explored. Here, we found a dynamic regulation of NgR1 expression during development and neuronal injury. NgR1 mRNA was consistently expressed in the brain from embryonic day 18 to postnatal day 25. In contrast, its expression significantly decreased in the spinal cord during development. Primary cultured neurons, microglia, and astrocytes expressed NgR1. Interestingly, a contusion injury in the spinal cord led to elevated NgR1 mRNA expression at the injury site, but not in the motor cortex, 14 days after injury. Consistent with this, astrocyte activation by TGFb1 increased NgR1 expression, while microglia activation rather decreased NgR1 expression. These results collectively suggest that NgR1 expression is enhanced in a milieu of neural injury. Our findings may provide insight into the roles of NgR1 in glial cells.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalNagoya journal of medical science
Volume78
Issue number3
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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