Noise-enhanced heart rate and sympathetic nerve responses to oscillatory lower body negative pressure in humans

Ichiro Hidaka, Shin Ichi Ando, Hideaki Shigematsu, Koji Sakai, Soko Setoguchi, Taku Seto, Yoshitaka Hirooka, Akira Takeshita, Yoshiharu Yamamoto

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

By injecting noise into the carotid sinus baroreceptors, we previously showed that heart rate (HR) responses to weak oscillatory tilt were enhanced via a mechanism known as "stochastic resonance." It remains unclear, however, whether the same responses would be observed when using oscillatory lower body negative pressure (LBNP), which would unload the cardiopulmonary baroreceptors with physically negligible effects on the arterial system. Also, the vasomotor sympathetic activity directly controlling peripheral resistance against hypotensive stimuli was not observed. We therefore investigated the effects of weak (0 to approximately -10 mmHg) oscillatory (0.03 Hz) LBNP on HR and muscle sympathetic nerve activity (MSNA) while adding incremental noise to the carotid sinus baroreceptors via a pneumatic neck chamber. The signal-to-noise ratio of HR, cardiac interbeat interval, and total MSNA were all significantly improved by increasing noise intensity, while there was no significant change in the arterial blood pressure in synchronized with the oscillatory LBNP. We conclude that the stochastic resonance, affecting both HR and MSNA, results from the interaction of noise with the signal in the brain stem, where the neuronal inputs from the arterial and cardiopulmonary baroreceptors first come together in the nucleus tractus solitarius. Also, these results indicate that the noise could induce functional improvement in human blood pressure regulatory system in overcoming given hypotensive stimuli.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalJournal of Neurophysiology
Volume86
Issue number2
Publication statusPublished - Aug 22 2001

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Lower Body Negative Pressure
Pressoreceptors
Noise
Heart Rate
Carotid Sinus
Myocardium
Solitary Nucleus
Signal-To-Noise Ratio
Vascular Resistance
Brain Stem
Arterial Pressure
Neck
Blood Pressure
Muscles

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Hidaka, I., Ando, S. I., Shigematsu, H., Sakai, K., Setoguchi, S., Seto, T., ... Yamamoto, Y. (2001). Noise-enhanced heart rate and sympathetic nerve responses to oscillatory lower body negative pressure in humans. Journal of Neurophysiology, 86(2), 559-564.

Noise-enhanced heart rate and sympathetic nerve responses to oscillatory lower body negative pressure in humans. / Hidaka, Ichiro; Ando, Shin Ichi; Shigematsu, Hideaki; Sakai, Koji; Setoguchi, Soko; Seto, Taku; Hirooka, Yoshitaka; Takeshita, Akira; Yamamoto, Yoshiharu.

In: Journal of Neurophysiology, Vol. 86, No. 2, 22.08.2001, p. 559-564.

Research output: Contribution to journalArticle

Hidaka, I, Ando, SI, Shigematsu, H, Sakai, K, Setoguchi, S, Seto, T, Hirooka, Y, Takeshita, A & Yamamoto, Y 2001, 'Noise-enhanced heart rate and sympathetic nerve responses to oscillatory lower body negative pressure in humans', Journal of Neurophysiology, vol. 86, no. 2, pp. 559-564.
Hidaka I, Ando SI, Shigematsu H, Sakai K, Setoguchi S, Seto T et al. Noise-enhanced heart rate and sympathetic nerve responses to oscillatory lower body negative pressure in humans. Journal of Neurophysiology. 2001 Aug 22;86(2):559-564.
Hidaka, Ichiro ; Ando, Shin Ichi ; Shigematsu, Hideaki ; Sakai, Koji ; Setoguchi, Soko ; Seto, Taku ; Hirooka, Yoshitaka ; Takeshita, Akira ; Yamamoto, Yoshiharu. / Noise-enhanced heart rate and sympathetic nerve responses to oscillatory lower body negative pressure in humans. In: Journal of Neurophysiology. 2001 ; Vol. 86, No. 2. pp. 559-564.
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