Noise-Induced Acceleration of Single Molecule Kinesin-1

Takayuki Ariga, Keito Tateishi, Michio Tomishige, Daisuke Mizuno

Research output: Contribution to journalArticlepeer-review

Abstract

The movement of single kinesin molecules was observed while applying noisy external forces that mimic intracellular active fluctuations. We found kinesin accelerates under noise, especially when a large hindering load is added. The behavior quantitatively conformed to a theoretical model that describes the kinesin movement with simple two-state reactions. The universality of the kinetic theory suggests that intracellular enzymes share a similar noise-induced acceleration mechanism, i.e., active fluctuations in cells are not just noise but are utilized to promote various physiological processes.

Original languageEnglish
Article number178101
JournalPhysical review letters
Volume127
Issue number17
DOIs
Publication statusPublished - Oct 22 2021

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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