Non-covalent coating of liposome surface with igg through its constant region

Hikari Sato, Yoshiki Miyashita, Koichi Sasaki, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Here we present a liposome non-covalently coated with immunoglobulin G (IgG) by using a peptide ligand to the constant region of IgG. IgG coated on the liposome still maintained binding ability to a complementary antigen protein but it was not recognized by Fcγ receptors (FcγRs) of monocytes. The stealth feature of the IgG-coated liposome may be useful to avoid clearance by macrophages in vivo to extend the blood half-life of the liposome.

Original languageEnglish
Pages (from-to)770-772
Number of pages3
JournalChemistry Letters
Volume47
Issue number6
DOIs
Publication statusPublished - Jan 1 2018

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Liposomes
Immunoglobulin G
Coatings
Fc Receptors
Macrophages
Blood
Ligands
Antigens
Peptides
Proteins

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Non-covalent coating of liposome surface with igg through its constant region. / Sato, Hikari; Miyashita, Yoshiki; Sasaki, Koichi; Kishimura, Akihiro; Mori, Takeshi; Katayama, Yoshiki.

In: Chemistry Letters, Vol. 47, No. 6, 01.01.2018, p. 770-772.

Research output: Contribution to journalArticle

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AU - Mori, Takeshi

AU - Katayama, Yoshiki

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