TY - JOUR
T1 - Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C−H Oxidation
AU - Doiuchi, Daiki
AU - Nakamura, Tatsuya
AU - Hayashi, Hiroki
AU - Uchida, Tatsuya
N1 - Funding Information:
Financial Support from JSPS KAKENHI Grant Number 18H04264 in Precisely Designed Catalysis with Customized Scaffolding; The International Institute for Carbon-Neutral Energy Research (WPI-I2CNER) from MEXT, Japan, are grateful acknowledged.
Publisher Copyright:
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/3/16
Y1 - 2020/3/16
N2 - Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C−H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C−H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.
AB - Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C−H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C−H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.
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U2 - 10.1002/asia.202000134
DO - 10.1002/asia.202000134
M3 - Article
C2 - 32072734
AN - SCOPUS:85080137165
SN - 1861-4728
VL - 15
SP - 762
EP - 765
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
IS - 6
ER -