Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C−H Oxidation

Daiki Doiuchi, Tatsuya Nakamura, Hiroki Hayashi, Tatsuya Uchida

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C−H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C−H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.

Original languageEnglish
Pages (from-to)762-765
Number of pages4
JournalChemistry - An Asian Journal
Volume15
Issue number6
DOIs
Publication statusPublished - Mar 16 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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