TY - JOUR
T1 - Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats
AU - Iwasaki, Katsunori
AU - Chung, Eun Hee
AU - Egashira, Nobuaki
AU - Hatip-Al-Khatib, Izzettin
AU - Mishima, Kenichi
AU - Egawa, Takashi
AU - Irie, Keiichi
AU - Fujiwara, Michihiro
N1 - Funding Information:
This study was supported by the Advanced Materials Institute, Fukuoka University.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2004/1/2
Y1 - 2004/1/2
N2 - The spatial memory impairment and expression of apoptotic cells in hippocampal CA1 cells were investigated in rats using single and repeated ischemia models. The neuroprotective and memory-improving effect of YM-90K, an α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor antagonist, was compared to MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist. Twice-repeated ischemia, but not single ischemia, impaired the spatial memory and increased expression of apoptotic cells. YM-90K, given before and 6 h after the second reperfusion, significantly improved the memory and reduced the apoptotic cells 7 days after the second reperfusion in repeated ischemia. MK-801 neither improved the spatial memory nor reduced apoptotic cells. The present study showed that delayed expression of apoptotic cells is mediated by mechanisms involving AMPA receptors, but not by NMDA receptor, during the late phase after reperfusion. YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia.
AB - The spatial memory impairment and expression of apoptotic cells in hippocampal CA1 cells were investigated in rats using single and repeated ischemia models. The neuroprotective and memory-improving effect of YM-90K, an α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor antagonist, was compared to MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist. Twice-repeated ischemia, but not single ischemia, impaired the spatial memory and increased expression of apoptotic cells. YM-90K, given before and 6 h after the second reperfusion, significantly improved the memory and reduced the apoptotic cells 7 days after the second reperfusion in repeated ischemia. MK-801 neither improved the spatial memory nor reduced apoptotic cells. The present study showed that delayed expression of apoptotic cells is mediated by mechanisms involving AMPA receptors, but not by NMDA receptor, during the late phase after reperfusion. YM-90K could provide neuroprotective activity and improve the spatial memory impaired by repeated ischemia.
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U2 - 10.1016/j.brainres.2003.09.064
DO - 10.1016/j.brainres.2003.09.064
M3 - Article
C2 - 14644478
AN - SCOPUS:0344872608
SN - 0006-8993
VL - 995
SP - 131
EP - 139
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1
ER -