Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice

Fuminori Kawabata, Naohiko Inoue, Yukiko Masamoto, Shigenobu Matsumura, Wakako Kimura, Makoto Kadowaki, Tomohiro Higashi, Makoto Tominaga, Kazuo Inoue, Tohru Fushiki

Research output: Contribution to journalArticle

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Abstract

Capsinoids are non-pungent capsaicin analogs which increase energy expenditure like capsaicin. However, the mechanisms underlying the enhancement of their energy expenditure despite their non-pungency are poorly understood. We suggest here that capsinoids increase energy expenditure in wild-type mice, but not in transient receptor potential vanilloid 1 (TRPV1) knockout mice, implying that capsinoids increase energy expenditure via TRPV1. The jejunal administration of capsinoids to anesthetized mice raised the temperature of the colon and intrascapular brown adipose tissue. Denervation of the extrinsic nerves connected to the jejunum inhibited this temperature elevation. These findings suggest that capsinoids increase energy expenditure by activating the intestinal extrinsic nerves. Although the jejunal administration of capsinoids did not raise the tail skin temperature, an intravenous injection of capsinoids did, indicating that capsinoids could barely pass through the intestinal wall into the blood. Taken together, gastrointestinal TRPV1 may be a critical target for capsinoids to enhance energy expenditure.

Original languageEnglish
Pages (from-to)2690-2697
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number12
DOIs
Publication statusPublished - Dec 1 2009

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Thermogenesis
Capsaicin
Energy Metabolism
Temperature
Brown Adipose Tissue
Skin Temperature
Denervation
Jejunum
Knockout Mice
Intravenous Injections
vanilloid receptor subtype 1
Tail
Skin
Colon
Blood
Tissue

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. / Kawabata, Fuminori; Inoue, Naohiko; Masamoto, Yukiko; Matsumura, Shigenobu; Kimura, Wakako; Kadowaki, Makoto; Higashi, Tomohiro; Tominaga, Makoto; Inoue, Kazuo; Fushiki, Tohru.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 12, 01.12.2009, p. 2690-2697.

Research output: Contribution to journalArticle

Kawabata, F, Inoue, N, Masamoto, Y, Matsumura, S, Kimura, W, Kadowaki, M, Higashi, T, Tominaga, M, Inoue, K & Fushiki, T 2009, 'Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice', Bioscience, Biotechnology and Biochemistry, vol. 73, no. 12, pp. 2690-2697. https://doi.org/10.1271/bbb.90555
Kawabata, Fuminori ; Inoue, Naohiko ; Masamoto, Yukiko ; Matsumura, Shigenobu ; Kimura, Wakako ; Kadowaki, Makoto ; Higashi, Tomohiro ; Tominaga, Makoto ; Inoue, Kazuo ; Fushiki, Tohru. / Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. In: Bioscience, Biotechnology and Biochemistry. 2009 ; Vol. 73, No. 12. pp. 2690-2697.
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