Nonequilibrium Energetics of Molecular Motor Kinesin

Takayuki Ariga, Michio Tomishige, Daisuke Mizuno

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Nonequilibrium energetics of single molecule translational motor kinesin was investigated by measuring heat dissipation from the violation of the fluctuation-response relation of a probe attached to the motor using optical tweezers. The sum of the dissipation and work did not amount to the input free energy change, indicating large hidden dissipation exists. Possible sources of the hidden dissipation were explored by analyzing the Langevin dynamics of the probe, which incorporates the two-state Markov stepper as a kinesin model. We conclude that internal dissipation is dominant.

Original languageEnglish
Article number218101
JournalPhysical Review Letters
Volume121
Issue number21
DOIs
Publication statusPublished - Nov 21 2018

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dissipation
probes
free energy
cooling
molecules

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Nonequilibrium Energetics of Molecular Motor Kinesin. / Ariga, Takayuki; Tomishige, Michio; Mizuno, Daisuke.

In: Physical Review Letters, Vol. 121, No. 21, 218101, 21.11.2018.

Research output: Contribution to journalArticle

Ariga, Takayuki ; Tomishige, Michio ; Mizuno, Daisuke. / Nonequilibrium Energetics of Molecular Motor Kinesin. In: Physical Review Letters. 2018 ; Vol. 121, No. 21.
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