Nonequilibrium mechanics of active cytoskeletal networks

Daisuke Mizuno, Catherine Tardin, C. F. Schmidt, F. C. MacKintosh

Research output: Contribution to journalArticlepeer-review

676 Citations (Scopus)


Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate-dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation.

Original languageEnglish
Pages (from-to)370-373
Number of pages4
Issue number5810
Publication statusPublished - Jan 19 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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