Noninvasive measurement of isovolumetric contraction time during hypoxemia and acidemia

Fetal lamb validation as an index of cardiac contractility

Yasuo Yumoto, Shoji Satoh, Yasuyuki Fujita, Tsuyoshi Koga, Naoko Kinukawa, Hitoo Nakano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives: The objectives of this study are firstly to clarify how the Doppler isovolumetric contraction time (ICT) is influenced by arterial oxygen pressure (PaO2) or pH, and secondly to confirm the relationship between the Doppler ICT and myocardial contractility during hypoxemia and/or acidemia in the fetal lamb. Material and methods: In 12 pregnant ewes, fetal hypoxemia and acidemia were induced by giving ewes a variable mixture of gases for 120 min. The chronological change of fetal PaO2, pH, Doppler ICT and maximum first derivative of the left ventricular pressure waveform (Max dp/dt) was recorded every 30 min. Results: Doppler ICT and PaO2 had no significant regression. On the other hand, Doppler ICT and pH demonstrated a significant negative regression. Moreover, one critical given pH point was indicated with statistical significance at 7.20 and the prolongation of the Doppler ICT was found more markedly in the range below the pH of 7.20 compared with the range above 7.20. A significant negative linear regression was found between the Doppler ICT and the Max dp/dt. Conclusion: The measurement of Doppler ICT enables us to predict severe acidosis and a decrease of myocardial contractility in the fetus.

Original languageEnglish
Pages (from-to)635-642
Number of pages8
JournalEarly Human Development
Volume81
Issue number7
DOIs
Publication statusPublished - Jul 1 2005

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Myocardial Contraction
Hypoxia
Ventricular Pressure
Acidosis
Linear Models
Arterial Pressure
Fetus
Gases
Oxygen

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Noninvasive measurement of isovolumetric contraction time during hypoxemia and acidemia : Fetal lamb validation as an index of cardiac contractility. / Yumoto, Yasuo; Satoh, Shoji; Fujita, Yasuyuki; Koga, Tsuyoshi; Kinukawa, Naoko; Nakano, Hitoo.

In: Early Human Development, Vol. 81, No. 7, 01.07.2005, p. 635-642.

Research output: Contribution to journalArticle

Yumoto, Yasuo ; Satoh, Shoji ; Fujita, Yasuyuki ; Koga, Tsuyoshi ; Kinukawa, Naoko ; Nakano, Hitoo. / Noninvasive measurement of isovolumetric contraction time during hypoxemia and acidemia : Fetal lamb validation as an index of cardiac contractility. In: Early Human Development. 2005 ; Vol. 81, No. 7. pp. 635-642.
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